Research Divisions

Platelets: Biology, Pathology and Therapeutic Applications

Group LeaderLocation and ContactMembersHistory of the GroupLines of ResearchNotable PublicationsProjectsPhD ThesesClinical TrialsPatents and TrademarksNews
Dra. Laura Gutiérrez
Dr Laura Gutiérrez

Laura Gutiérrez Gutiérrez obtained her Bachelor’s degree in Biology (Fundamental Biology and Biotechnology) at the Faculty of Biology, Universidad de Oviedo (Spain), in 1998. She obtained an MSc in Biotechnology in 2000 at the University of Leicester (United Kingdom, with Distinction), having completed her Master’s dissertation under the supervision of Dr A. de Klein from the Genetics Department (ErasmusMC, Rotterdam, the Netherlands). She then joined the Cell Biology Department in ErasmusMC as a PhD researcher, initially supervised by Professor D. Whyatt, and obtained her PhD in 2005 (thesis title: “Studies on Gata1: Cell Cycle, Survival and Differentiation”), under the supervision of Professor F. Grosveld and co-supervised by Professor J. Philipsen.

She continued in the Cell Biology Department as a postdoctoral researcher in Professor J. Philipsen’s research group, where she developed her own lines of research, focusing on haematopoietic lineage specification and the role of Gata1 in these processes.

She was awarded a VENI grant (Netherlands Organisation for Scientific Research -NWO- “Transcriptome-wise dendritic cell manipulation”) and she joined Sanquin Research (Amsterdam, Netherlands) in 2010 as a junior group leader in the Blood Cell Research Department (headed by Dr. T.K. van den Berg), where her research focused on megakaryopoiesis and platelet function. She returned to Spain on a Ramón y Cajal contract and, after two years at the Instituto de Investigación Sanitaria San Carlos (San Carlos Health Research Institute, Madrid), has been working at ISPA since January 2018 as Principal Investigator, affiliated with the Department of Medicine at the Universidad de Oviedo.

 

Orcid: http://orcid.org/0000-0001-8443-900X
Research Gate: https://www.researchgate.net/profile/Laura_Gutierrez11

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)

Laboratorio de Investigación en Plaquetas: biología, patología y aplicaciones terapéuticas

Edificio FINBA, Avenida Hospital Universitario s/n 33011, Oviedo, Spain.

Name Position
Laura Gutiérrez Gutiérrez Principal Investigator
Patricia Martínez Botía Severo Ochoa PhD Researcher
Andrea Acebes Huerta Postdoctoral Researcher
Adrián Rodríguez Rodríguez Student

Associated Clinical Staff

Name Position
Inmaculada Soto Ortega Associated Clinical Researcher.
Head of the Haemostasis and Haematology Section, HUCA
Daniel Martínez Carballeira Associated Clinical Researcher.
Specialist Health Professional (FEA) in Haematology, HUCA
Ángel Bernardo Gutiérrez Associated Clinical Researcher.
Coordinator of Haematology Department Laboratories, Medicine Laboratory Clinical Management Division, HUCA
Tamara de la Cera Martínez Associated Clinical Researcher.
Quality Control Coordinator for the Biochemical Medicine Laboratory, Central Laboratory, HUCA
Tamara Arias Fernández Associated Clinical Researcher.
FEA in Haematology, HUCA
Judit Fernández Fuertes Associated Clinical Researcher.
FEA in the Orthopaedic Surgery and Traumatology Division, Hospital de Cabueñes
Esteban López-Anglada Fernández Associated Clinical Researcher.
FEA in the Orthopaedic Surgery and Traumatology Division, HUCA
Alberto Caro Gómez Associated Clinical Researcher

 

The Platelets research group’s origins date back to 2010, when Laura Gutiérrez became head of her own research group as Junior Group Leader at Sanquin Research (Amsterdam, the Netherlands). At Sanquin Research, she supervised two PhD researchers, a senior laboratory technician and two postdoctoral researchers, publishing in specialised, high-impact scientific journals. In August 2015, she returned to Spain on a Ramón y Cajal contract, initially in the Instituto de Investigación Sanitaria San Carlos, where she supervised a postdoctoral researcher, a laboratory technician and students from the Spanish medical residency programme, who contributed to the group’s research projects and the production of thematic reviews. In January 2018, she moved to ISPA, establishing this research group by recruiting highly-respected associated clinical researchers and gradually incorporating PhD researchers and a postdoctoral researcher.

The work of the Platelets research group focuses on megakaryocytic differentiation, and the production and function of platelets in health and illness. Specifically, we are interested in the mechanisms of transcriptional regulation and protein translation during megakaryopoiesis: how they can be affected by haematological and non-haematological pathologies of different types and, in turn, affect platelet quality and function. We are particularly interested in megakaryocytic and haematopoietic differentiation, and how different conditions of stress or pathological situations influence this process. By understanding how haematopoiesis is regulated normally or in conditions of stress, we can use this knowledge to help develop new and/or personalised therapies. We take a multidisciplinary approach to research, and have therefore established collaborations with clinical departments such as psychiatry, ophthalmology, cardiovascular medicine, dermatology, paediatrics, etc. Through these collaborations, we intend to study the function or role or platelets in non-haematological pathologies, and also explore the use of platelets for diagnosis, prognosis and the development of platelet-based therapeutic applications.

  • Studying the physiopathology of congenital, acquired or autoimmune thrombocytopaenia, and thrombocytopaenia in other haematological pathologies.
  • Studying the mechanisms of platelet production and function in essential thrombocythaemia (collaboration with Dr Petros Papadopoulos, Hospital Clínico San Carlos, Madrid).
  • Studying the production and function of platelets in non-haematological pathologies.
  • Studying the function of platelets during embryo development, in newborns and infants.
  • Development of new platelet-based therapies.
  • AUTHORS: Acebes-Huerta A., Arias-Fernández T., Bernardo A., Muñoz-Turrillas M.C., Fernández-Fuertes J., Seghatchian J., Gutiérrez L.
    TITLE: Platelet-derived bio-products: classification update, applications, concerns and new perspectives.
    Transfus Apher Sci, 2019. In Press.
    IF 0.963; Q4
  • AUTHORS: Velasco A., Rodríguez-Revuelta J., Oliée E., Abadd I., Fernández-Peláez A., Cazalse A., Guillaumee S., de la Fuente-Tomás L., Jiménez-Treviño L., Gutiérrez L., García-Portilla P., Bobes J., Courtete P., Sáiz P.A.
    TITLE: Neutrophil-to-lymphocyte ratio: a potential new peripheral biomarker of suicidal behaviour.
    European Psychiatry, 2019, In Press.
    IF 3.941; Q1
  • AUTHORS: Gutiérrez L., Caballero N., Fernández-Calleja L., Karkoulia E., Strouboulis J.
    TITLE: Regulation of GATA1 levels in erythropoiesis.
    IUBMB Life, 2020, Volume 72, issue 1, pages 89-105.
    IF 3.051; Q1
  • AUTHORS: Scully D., Sfyri P., Wilkinson H.N., Acebes-Huerta A., Verpoorten S., Muñoz-Turrillas M.C., Parnell A., Patel P., Hardman M.J., Gutiérrez L. and Matsakas A.
    TITLE: Optimising platelet secretomes to deliver robust tissue-specific regeneration.
    Journal of Tissue Engineering and Regenerative Medicine, 2019. In Press.
    IF 4.089; Q1
  • AUTHORS: Ojea-Pérez A.M., Acebes-Huerta A., Arias-Fernández T, Gutiérrez L.⁎ and Muñoz-Turrillas M.C.*.
    *Equal contribution
    TITLE: Implementation of a closed platelet-rich-plasma preparation method using the local blood bank infrastructure at the Principality of Asturias (Spain): Back to basic methodology and a demographics perspective after 1 year.
    Transfus Apher Sci, 2019. Volume 98, issue 5, pages 701-704.
    IF 1.755; Q4
  • AUTHORS: Scully D., Sfyri P., Verpoorten S., Papadopoulos P., Muñoz-Turrillas M.C., Mitchell R., Aburima A., Patel K., Gutiérrez L., Naseem K.M. and Matsakas A.
    TITLE: Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury.
    Acta Physiologica, 2019. Volume 225, issue 3, e13207.
    IF 5.930; D1
  • AUTHORS: Salunkhe V., De Cuyper I.M., Papadopoulos P., van der Meer P.F., Daal B.B., Villa-Fajardo M., de Korte D., van den Berg T.K. and Gutiérrez L.
    TITLE: A Comprehensive Proteomics Study on Platelet Concentrates: Platelet Proteome, Storage Time and Mirasol Pathogen Reduction Technology.
    Platelets, 2019. Volume 30, issue 3, pages 368-379.
    IF 2.356; Q3
  • AUTHORS: Vicente-Ayuso M.C., Papadopoulos P., Villa-Fajardo M., Prieto B., Álvarez-Carmona A.M., Mateo-Morales M., Pérez-López C., Peña-Cortijo A., Polo-Zarzuela M., Sáez I., Martín M.P., Benavente-Cuesta C., González-Fernández A., Martínez-Martínez R., Zwaginga J.J., Seghatchian J. and Gutiérrez L.
    TITLE: Identification of underlying and transfusion-related platelet qualitative alterations in the hemato-oncologic patient.
    Transfus Apher Sci, 2017. Volume 56, pages 756-768.
    IF 0.963; Q4
  • AUTHORS: Vicente-Ayuso M.C., García-Roa M., González-Fernández A., Álvarez-Carmona A.M., Benavente-Cuesta C., Mateo-Morales M., Pérez-López C., Peña-Cortijo A., Polo Zarzuela M., Gutiérrez L. and Martínez-Martínez R.
    TITLE: Therapy-related myeloid neoplasms as a concerning complication in acute promyelocytic leukemia: a case report.
    Hematology Reports, 2017. Volume 9, Issue 3, pages 114-117.
    IF 0.7; Q3
  • AUTHORS: García-Roa M., Vicente-Ayuso M.C., Bobes A.M., Pedraza A.C., González-Fernández A., Martín M.P., Sáez I., Seghatchian J. and Gutiérrez L.
    TITLE: Red Blood Cell Storage Time and Transfusion: current practice, concerns and future perspectives.
    Blood Transfusion, 2017. Volume 15, Issue 3, pages 221-231.
    IF 1.514; Q4
  • AUTHORS: Scheenstra M.R., De Cuyper I.M., Branco-Madeira F., de Bleser P., Kool M., Meinders M., Hoogenboezem M., Mul E., Wolkers M.C., Salerno F., Nota B., Saeys Y., Klarenbeek S., van IJcken W.F.J., Hammad H., Philipsen S., van den Berg T.K., Kuijpers T.W., Lambrecht B.N. and Gutiérrez L.
    TITLE: GATA1-deficient dendritic cells display impaired CCL21-dependent migration towards lymph nodes due to reduced levels of polysialic acid.
    Journal of Immunology. 2016. Volume 197, issue 11, pages 4312-4324.
    IF 4.985; Q1
  • AUTHORS: Meinders M., Hoogenboezem M., Scheenstra M.R., De Cuyper I.M., Papadopoulos P., Németh T., Mócsai A., van den Berg T.K., Kuijpers T.W. and Gutiérrez L.
    TITLE: Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment.
    PLoS One, 2016. Volume 11, issue 5, e0154342.
    IF 3.057; Q1
  • AUTHORS: Salunkhe V., Papadopoulos P. and Gutiérrez L.
    TITLE: Culture of Megakaryocytes from Human Peripheral Blood Mononuclear Cells.
    Bio-Protocol, 2015. Volume 5, issue 21, e1639.
    IF N/A; Q N/A
  • AUTHORS: Scheenstra M.R., Salunkhe V., De Cuyper I.M., Hoogenboezem M., Li E., Kuijpers T.W., van den Berg T.K. and Gutiérrez L.
    TITLE: Characterization of hematopoietic GATA transcription factor expression in mouse and human dendritic cells.
    Blood Cells Mol Dis, 2015. Volume 55, issue 4, pages 293-303.
    IF 2.731; Q2
  • AUTHORS: Papadopoulos P., Gutiérrez L., Demmers J., Scheer E., Pourfarzad F., Papageorgiou D.N., Karkoulia E., Strouboulis J., van de Werken H.J.G., van der Linden R., Vandenberghe P., Dekkers D.H.W., Philipsen S., Grosveld F. and Tora L.
    TITLE: TAF10 interacts with GATA1 transcription factor and controls mouse erythropoiesis.
    Mol Cell Biol, 2015. Volume 35, issue 12, pages 2103-2118.
    IF 4.427; Q1
  • AUTHORS: Meinders M., Kulu D.I., van de Werken H.J.G., Hoogenboezem M., Janssen H., Brouwer R.W.W., van Ijcken W.F.J., Rijkers E.-J., Demmers J.A.A., Krüger I., van den Berg T.K., Suske G., Philipsen S.* and Gutiérrez L.*
    TITLE: Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation, and platelet formation and function.
    Blood, 2015. Volume 125, issue 12, pages 1957-1967. *equal contribution.
    IF 11.841; D1
  • AUTHORS: Salunkhe V., van der Meer P.F., de Korte D., Seghatchian J.* and Gutiérrez L.*
    TITLE: Development of blood transfusion product pathogen reduction treatments: a review of methods, current applications and demands.
    Transfus Apher Sci, 2015. Volume 52, issue 1, pages 19-34. *equal contribution.
    IF 0.963; Q4
  • AUTHORS: Zeddies S., De Cuyper I.M., van der Meer P.F., Daal B., de Korte D., Thijssen-Timmer D.C.* and Gutiérrez L.*
    TITLE: Pathogen reduction treatment using riboflavin and ultraviolet light impairs platelet reactivity towards specific agonists in vitro.
    Transfusion, 2014. Volume 54, issue 9, pages 2292-2300. *equal contribution.
    IF 3.042; Q2
  • AUTHORS: Bergink S., Theil A., Toussaint W., Clapes T., van der Linden R., Demmers J.A., Marteijn J.A., De Cuyper I.M., van Gent T., Robin C., Philipsen S., Vermeulen W., Mitchell J.* and Gutiérrez L.*
    TITLE: Erythropoietic defect associated with reduced cell proliferation in mice lacking the 26S proteasome shuttling factor Rad23b.
    Mol Cell Biol, 2013. Volume 33, issue 19, pages 3879-3892. *equal contribution.
    IF 4.427; Q1
  • AUTHORS: Fujita R., Takayama-Tsujimoto M., Satoh H., Gutiérrez L., Aburatani H., Fujii S., Sarai A., Bresnick E.H., Yamamoto M. and Motohashi H.
    TITLE: NF-E2 p45 Is Important for Establishing Normal Function of Platelets.
    Mol Cell Biol, 2013. Volume 33, issue 14, pages 2659-2670.
    IF 4.427; Q1
  • AUTHORS: De Cuyper I.M., Meinders M., van de Vijver E., de Korte D., Porcelijn L., de Haas M., Eble J.A., Seeger K., Rutella S., Pagliara D., Kuijpers T.W., Verhoeven A.J., van den Berg T.K. and Gutiérrez L.
    TITLE: A novel flow cytometry-based platelet aggregation assay.
    Blood, 2013. Volume 121, issue 10, e70-80.
    IF 11.841; D1
Principal Investigator Title Funding Body Duration Amount
Laura Gutiérrez Ramón y Cajal 2013 MINECO 5 years €308,600
Laura Gutiérrez R& D Excellence 2014: “Identifying time-window and composition of chemotherapy-induced plasma factors inhibiting platelet function in the onco-haematological patient” MINECO and FEDER (Spanish Federation of Rare Diseases) funds 3+1 years €145,200
Laura Gutiérrez Integrated Excellence Project 2016: “Microcirculatory dysfunction in stable coronary artery disease: relationship with patient-focused outcomes, cerebral small vessel disease and depression” – changed from principal investigator to collaborating researcher upon transferring to ISPA. ISCIII 3 years €376,200 (€39,650 allocated to the group)
Laura Gutiérrez AMGEN 2017: “Studies on the physiopathology of Immune Thrombocytopenia (ITP) based on antibody platelet receptor target and development of direct diagnostic methods” AMGEN 2 years €63,600
Laura Gutiérrez R&D Excellence: “Development of Platelet-based Alternative Therapies through Omics and Innovation” Ministerio de Ciencia, Innovación y Universidades and FEDER funds 3 years €145,200.00
Laura Gutiérrez and María Carmen Muñoz Fresenius Kabi 2018: “Characterisation of active components in platelet-rich plasma (PRP) produced in a closed system” Fresenius Kabi 1 year €7,000
Laura Gutiérrez and Inmaculada Soto SOBI 2019: “Characterisation of the platelet proteome of haemophiliac patients and study of its association with clinical manifestations” SOBI 2 years €22,000
PhD Student Tutor Supervisor Title Year
Marjolein Meinders Prof. T.K. Kuijpers Laura Gutiérrez Studies of megak aryopoiesis and platelet function. 2015 European Honours
Maaike Scheenstra Prof. T.K. Kuijpers Laura Gutiérrez Studies of Gata1 and PU.1 in dendritic cells: mice are not human. 2018 European Honours