Research Divisions

Bone Metabolism, Vascular Metabolism and Chronic Inflammatory Diseases

Group LeaderLocation and ContactMembersHistory of the GroupLines of ResearchNotable PublicationsProjectsPhD ThesesCollaborationsNews
Dr. Jorge B. Cannata
Professor Jorge B. Cannata

Jorge Benito Cannata Andía

Posts and Main Positions of Responsibility

Professor of Medicine at the Universidad de Oviedo. Director of the Bone Metabolism Clinical Management Unit, Hospital Universitario Central de Asturias (HUCA). Chair of the Renal Section and of the Board of the European Union of Medical Specialists (UEMS ). Ex-president of the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) (2005-2008) and the Sociedad Española de Investigaciones Óseas y Metabolismo Mineral (Spanish Bone Research and Mineral Metabolism Society; 1991-1995). Chair of the ERA-EDTA Education Committee (2013-2016). Member of the Committee of Scientific Advisors for the International Osteoporosis Foundation (2004-2018). Research Institute Accreditation Auditor for the Instituto de Salud Carlos III (2011-2018). Member of the ERA-EDTA Scientific Advisory Board (2011-2014). Member of the Board for the International Nephrology Society (2009-2015) and ERA-EDTA (1993-1997). Chair of the 54th European Nephrology, Dialysis and Transplant Conference (2017). ERA-EDTA Secretary-Treasurer (2002-2005) and Treasurer of the Sociedad Española de Nefrología (Spanish Nephrology Society; 1987-1993).

Relevant Honours and Awards

  • IOF President’s Award 2016
  • ERA-EDTA Award 2013
  • National Kidney Foundation Gold Medal (US) 2006
  • Fundación Renal Iñigo Álvarez de Toledo (Iñigo Álvarez de Toledo Kidney Foundation) Award 1990 and 1995.
  • Honorary Member of the Nephrology Societies of Argentina, Spain, Hungary, Latin America, Portugal, Uruguay, and the Sociedad Española de Diálisis y Trasplante (Spanish Dialysis and Transplant Society).

 

Main Lines of Research

  • Toxicology of aluminium.
  • Bone and mineral metabolism disorders in the general population and in chronic kidney disease. Vascular calcification, bone demineralisation and ageing .

 

Scientific Output, Projects and Indices.

520 original articles and editorials, 97 book chapters, 72 projects and research contracts, 353 international conferences, 171 national conferences. Cumulative Impact factor: 1278 , Hirsch Index: 50 Citations: 10,523.

Edificio Consultas Externas HUCA, Nivel 0, Bloque B and Edificio FINBA – F1.1 Laboratorio 14.

Avda Hospital Universitario s/n, 33011 Oviedo, Spain.

Telephone: +34 985106137

E-mail: cannata@hca.es

The Bone Metabolism, Vascular Metabolism and Chronic Inflammatory Diseases research group is a multidisciplinary team which is committed to the translation of results and performs its research in the clinical, epidemiological and experimental fields. Its work falls within the “Demographic Ageing and Quality of Life” section of the RIS3 Smart Specialisation Strategy for Asturias. The research group is currently composed of the following members:

Name Organisation Activity Euraxess classification
Alonso Montes, Cristina FINBA Research R3
Avello Llano, Noelia SESPA Research/Clinical R2
Barrera Baena, Pedro Universidad de Oviedo Research R1
Cannata Andía, Jorge Benito Universidad de Oviedo Research/Clinical/Teaching R4
Carrillo López, Natalia FINBA Research R3
Díaz Sottolano, Augusto Antonio SESPA Research R1
Fernández Martín, José Luis SESPA Research/Clinical R3
Fernández Villabrille, Sara FINBA Research R1
Gómez Alonso, Carlos SESPA Research/Clinical R2
Martín Carro, Beatriz FINBA Research R1
Martín Virgala, Julia FINBA Research R1
Naves Díaz, Manuel SESPA Research/Clinical R4
Palomo Antequera, Carmen SESPA Research/Clinical R2
Panizo García, Sara FINBA Research R3
Rodríguez García, Minerva SESPA Research/Clinical R2
Rodríguez Suárez, Carmen SESPA Research/Clinical R2
Sánchez Álvarez, José Emilio SESPA Research/Clinical R2
Sobrino Díaz, Lucía SESPA Research/Clinical R2
Ulloa Clavijo, Catalina SESPA Research/Clinical R2
Sanz García, Clara SESPA Research No classification
Bone Metabolism, Vascular Metabolism and Chronic Inflammatory Diseases
Bone Metabolism, Vascular Metabolism and Chronic Inflammatory Diseases

The H-indices (Web of Science database – FECYT) of the group’s “senior” members are as follows: Jorge Cannata-Andía 50, Adriana Dusso 37, Manuel Naves 27, José Luis Fernández Martín 20, Natalia Carrillo López 10, Emilio Sánchez Álvarez 9, Minerva Rodríguez García, Carmen Rodríguez Suárez and Cristina Alonso Montes 8 (June 2018).

The group has published over 650 articles (90% in English), edited two books and produced more than 100 book chapters, its English publications having an average impact factor of 5.39. The group’s scientific output has maintained a consistent level of quality over the last decade, with 60-70% of its publications appearing in Q1 journals, and 15-25% of these within the top decile. It has also received over 50 awards, four of which were related to scientific careers and training.

The group leader and principal investigator was Research Coordinator and Chair of the Research Commission for the Hospital Universitario Central de Asturias (HUCA) between 1993 and 2007: the period in which most of HUCA’s research infrastructure was consolidated. He has been Research Institute Accreditation Auditor for Instituto de Salud Carlos III since 2010, and is an honorary member of eight scientific societies (six of which are international).

The research group was consolidated in 1987, initially focusing exclusively on the bone and mineral metabolism disorders that occur as a result of decreased kidney function and ageing, before gradually incorporating vascular and valvular calcification into its lines of research. The research group formed part of the Bone and Mineral Metabolism Department of the Hospital General de Asturias, which became part of the Hospital Universitario Central de Asturias after the hospitals were merged. The group was part of IRSIN (Reina Sofía Research Institute) at the Fundación Renal Íñigo Álvarez de Toledo (Íñigo Álvarez de Toledo Kidney Foundation) from the date IRSIN was created in 1994 until 2016, when it was dissolved. It has also been a member of REDinREN (the cooperative Renal Research Network) since 2008 (ISCIII-Retic-RD06/0016/06, RD12/0021/1023 and RD16/0009/0017) and has been an Universidad de Oviedo approved research group since 2013.

The group which developed out of the initial formation consolidated in 1987 has designed, led and conducted 12 clinical-epidemiological research projects, 32 clinical-experimental projects and 28 basic-experimental projects. Forty-four of these projects were competitively funded (by state or international RDI organisations) and 28 were non-competitively funded (through contracts and/or research agreements).

Of those allocated non-competitive funding, it is worth highlighting two large-scale, international epidemiological studies designed, led and conducted by the Bone and Mineral Metabolism research group: the CORES (Controlling Renal Osteodystrophy in South America) project, with 16173 patients in six South American countries, completed in 2012 (Argentina, Brazil, Chile, Colombia, Mexico and Venezuela); and the COSMOS (Current Management Of Secondary Hyperparathyroidism: a Multicentre Observational Study) project, with 6797 patients at 227 sites in 20 European countries (Austria, Belgium, Croatia, Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Italy, the Netherlands, Poland, Portugal, Romania, Slovenia, Spain, Sweden, Switzerland and the United Kingdom).

In addition to the CORES, COSMOS and other research projects mentioned above, the Bone and Mineral Metabolism group has completed 11 international cooperation interventions, supported by partnerships with the Spanish Ministry of Education – British Council (5), the Agencia Española de Cooperación Internacional para el Desarrollo (Spanish Agency for International Development Cooperation ; 4), the University of Antwerp (Belgium) and the Universidade de São Paulo (Brazil).

  • Epidemiology, diagnosis and treatment of mineral and bone metabolism disorders in stage 5 chronic kidney disease (CKD-MBD). COSMOS Study.
  • Molecular mechanisms involved in vascular calcification, mineralisation, ageing, immunological disorders and chronic kidney disease (CKD).
  • Synergy between vitamin D and β-glucans in mitigating vascular and immunological ageing of the renal vascular and cardiovascular tissue.
  • Identification of early biomarkers for endothelial damage and cardiovascular risk. Determination of mechanisms of action.
  • The usefulness of genetic and molecular markers in early diagnosis of a chronic decrease in kidney function.
  • Molecular mechanisms of valvular calcification in severe aortic stenosis and restenosis in stents.
  • Studying microRNAs that regulate the RANK/RANKL/OPG pathway as predictors of vascular mineralisation (calcification) and bone demineralisation.
  • The role of exosomes in mineral metabolism disorders and inflammation.

Journal Publications

The group has published a total of 88 articles in the last five years: 74 in English and 14 in Spanish. Of the English-language publications, 39 appear in Q1 journals and nine in Q2 publications, with a cumulative impact factor of 354.1. We have selected 25 of these publications which represent the results of the group’s lines of research, and some of its collaborations:

  • Alonso-Montes C, Martín M, Martínez-Arias L, Coto E, Naves-Díaz M, Morís C, Cannata-Andía JB, Rodríguez I. Variants in cardiac GATA genes associated with bicuspid aortic valve. Eur J clin Invest., 2018 Sep 19:e13027. doi: 10.1111/eci.13027. I.F.: 3.086 Quartile: Q1
  • Rodríguez-Carrio J, Martinez-Zapico A, Cabezas-Rodríguez I, Benavente L, Pérez-Álvarez AI, López P, Cannata-Andía JB, Naves Díaz M, Suárez A. Clinical and subclinical cardiovascular disease in female SLE patients: interplay between body mass index and bone mineral density. Nutrition, Metabolism and Cardiovascular Diseases, 2018 (in press). I.F.: 3.318 Quartile: Q2
  • Fernández-Martín JL, Dusso A, Martínez-Camblor P, Dionisi MP, Floege J,Ketteler M, London G, Locatelli F, Górriz JL, Rutkowski B, Bos WJ, Tielemans C, Martin PY, Wüthrich RP, Pavlovic D, Benedik M, Rodríguez-Puyol D, Carrero JJ, Zoccali C, Cannata-Andía JB. Serum phosphate optimal timing and range associated with patients survival in haemodialysis: the COSMOS study. Nephrol Dial Transplant. 2018 May 7. doi: 10.1093/ndt/gfy093. IF.: 4.470 Quartile: Q1
  • Fusaro M, Cannata-Andía JB, Nickolas TL, Plebani M, Mereu MC, Aghi A, Gallieni M. Clinical relevance and future perspective of fractures in patients withchronic kidney disease. Kidney Int. 2018 May;93(5):1248. doi:10.1016/j.kint.2018.02.012. IF.: 8.395 Quartile: Q1(D1)
  • Dusso A, Colombo MI, Shanahan CM. Not all vascular smooth muscle cell exosomes calcify equally in chronic kidney disease. Kidney Int 93:298-301, 2018. IF.: 8.395 Quartile: Q1(D1)
  • Panizo S, Carrillo-López N, Naves-Díaz M, Solache-Berrocal G, Martínez-Arias L, Rodrigues-Díez RR, Fernández-Vázquez A, Martínez-Salgado C, Ruiz-Ortega M, Dusso A, Cannata-Andía JB, Rodríguez I. Regulation of miR-29b and miR-30c by vitamin D receptor activators contributes to attenuate uraemia-induced cardiacfibrosis. Nephrol Dial Transplant. 2017 Nov 1;32(11):1831-1840. doi:10.1093/ndt/gfx060. IF.: 4.470 Quartile: Q1
  • Alonso-Montes C, Rodríguez-Reguero J, Martín M, Gómez J, Coto E, Naves-Díaz M, Morís C, Cannata-Andía JB, Rodríguez I. Rare genetic variants in GATAtranscription factors in patients with hypertrophic cardiomyopathy. J InvestigMed. 2017 Jun;65(5):926-934. doi: 10.1136/jim-2016-000364. IF.: 1.943 Quartile: Q2
  • Moyses RMA, Dusso A. Is osteocyte Klotho bad for bone health? Kidney Int 92:540-543, 2017. IF.: 8.395 Quartile: Q1(D1)
  • Evenepoel P, D’Haese P, Bacchetta J, Cannata-Andia J, Ferreira A, Haarhaus M, Mazzaferro S, Lafage Proust MH, Salam S, Spasovski G, Cozzolino M, CKD-MBD E-EWGo. Bone biopsy practice patterns across Europe: the European renal osteodystrophy initiative-a position paper. Nephrol Dial Transplant 32:1608-1613, 2017. IF.: 4.470 Quartile: Q1
  • Armbrecht G, Felsenberg D, Ganswindt M, Lunt M, Kaptoge SK, Abendroth K, Aroso Dias A, Bhalla AK, Cannata Andia J, Dequeker J, Eastell R, Hoszowski K, Lyritis G, Masaryk P, van Meurs J, Miazgowski T, Nuti R, Poor G, Redlund-Johnell I, Reid DM, Schatz H, Todd CJ, Woolf AD, Rivadeneira F, Javaid MK, Cooper C, Silman AJ, O’Neill TW, Reeve J, European Vertebral Osteoporosis S, European Prospective Osteoporosis Study G. Degenerative inter-vertebral disc disease osteochondrosis intervertebralis in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over. Rheumatology (Oxford) 56:1189-1199, 2017. IF.: 4.818 Quartile: Q1
  • N. Carrillo-López, S. Panizo, C. Alonso-Montes, P. Román-García, I. Rodríguez García, C. Martinez-Salgado, A. Dusso, M. Naves Díaz, J. B. Cannata-Andía. Direct inhibition of osteoblastic Wnt pathway by fibroblast growth factor 23 contributes to bone loss in chronic kidney disease. Kidney Int. 2016 Jul;90(1):77-89. IF.: 8.395 Quartile: Q1(D1)
  • J. B. Cannata-Andia, K. J. Martin. The challenge of controlling phosphorus in chronic kidney disease. Nephrol Dial Transplant. 2016 Apr;31(4):541-7. IF.: 4.470 Quartile: Q1
  • I. Quiros-Gonzalez, P. Roman-Garcia, C. Alonso-Montes, S. Barrio-Vazquez, N. Carrillo-Lopez, M. Naves-Diaz, M. I. Mora, F. J. Corrales, F. J. Lopez-Hernandez, M. P. Ruiz-Torres, J. B. Cannata-Andia, J. L. Fernandez-Martin. Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load. Bone 84: 160-8; 2016. IF.:4.140 Quartile: Q1
  • J. L. Fernandez-Martin, P. Martinez-Camblor, M. P. Dionisi, J. Floege, M. Ketteler, G. London, F. Locatelli, J. L. Gorriz, B. Rutkowski, A. Ferreira, W. J. Bos, A. Covic, M. Rodriguez-Garcia, J. E. Sanchez, D. Rodriguez-Puyol, J. B. Cannata-Andia. Improvement of mineral and bone metabolism markers is associated with better survival in haemodialysis patients: the COSMOS study. Nephrol Dial Transplant 30: 1542-51; 2015. IF.: 4.470 Quartile: Q1
  • S. Panizo, M. Naves-Diaz, N. Carrillo-Lopez, L. Martinez-Arias, J. L. Fernandez-Martin, M. P. Ruiz-Torres, J. B. Cannata-Andia, I. Rodriguez. MicroRNAs 29b, 133b, and 211 Regulate Vascular Smooth Muscle Calcification Mediated by High Phosphorus. J Am SocNephrol 27: 824-34; 2016. IF.:8.966 Quartile: Q1 (D1)
  • D. Tuñón-Le Poultel, J. B. Cannata-Andia, P. Roman-Garcia, J. B. Diaz-Lopez, E. Coto, C. Gomez, M. Naves-Diaz, I. Rodriguez. Association of matrix Gla protein gene functional polymorphisms with loss of bone mineral density and progression of aortic calcification. OsteoporosInt 25: 1237-1246; 2014. IF.: 3.591 Quartile: Q2
  • P. Roman-Garcia, I. Quiros-Gonzalez, L. Mottram, L. Lieben, K. Sharan, A. Wangwiwatsin, J. Tubio, K. Lewis, D. Wilkinson, B. Santhanam, N. Sarper, S. Clare, G. S. Vassiliou, V. R. Velagapudi, G. Dougan, V. K. Yadav. Vitamin B(1)(2)-dependent taurine synthesis regulates growth and bone mass. J ClinInvest 124: 2988-3002; 2014. IF.: 12.784 Quartile: Q1 (D1)
  • A. Betriu, M. Martinez-Alonso, M. V. Arcidiacono, J. Cannata-Andia, J. Pascual, J. M. Valdivielso, E. Fernandez. Prevalence of subclinical atheromatosis and associated risk factors in chronic kidney disease: the NEFRONA study. Nephrol Dial Transplant 29: 1415-22; 2014. IF.: 4.470 Quartile: Q1
  • J. M. Quesada-Gomez, M. Diaz-Curiel, M. Sosa-Henriquez, J. Malouf-Sierra, X. Nogues-Solan, C. Gomez-Alonso, L. Rodriguez-Manas, J. L. Neyro-Bilbao, X. Cortes, J. Delgadillo. Low calcium intake and inadequate vitamin D status in postmenopausal osteoporotic women. J Steroid BiochemMolBiol 136: 175-7; 2013. IF.:4.561 Quartile: Q1
  • S. Panizo, S. Barrio-Vazquez, M. Naves-Diaz, N. Carrillo-Lopez, I. Rodriguez, A. Fernandez-Vazquez, J. M. Valdivielso, R. Thadhani, J. B. Cannata-Andia. Vitamin D receptor activation, left ventricular hypertrophy and myocardial fibrosis. Nephrol Dial Transplant 28: 2735-44; 2013. IF.: 4.470 Quartile: Q1
  • J. L. Fernandez-Martin, J. J. Carrero, M. Benedik, W. J. Bos, A. Covic, A. Ferreira, J.Floege, D. Goldsmith, J. L. Gorriz, M. Ketteler, R. Kramar, F. Locatelli, G. London, P. Y. Martin, D. Memmos, J. Nagy, M. Naves-Diaz, D. Pavlovic, M. Rodriguez-Garcia, B. Rutkowski, V. Teplan, C. Tielemans, D. Verbeelen, R. P. Wuthrich, P. Martinez-Camblor, I. Cabezas-Rodriguez, J. E. Sanchez-Alvarez, J. B. Cannata-Andia. COSMOS: the dialysis scenario of CKD-MBD in Europe. Nephrol Dial Transplant 28: 1922-35; 2013. IF.:4.470 Quartile: Q1
  • J. B. Cannata-Andia, J. L. Fernandez-Martin, F. Locatelli, G. London, J. L. Gorriz, J. Floege, M. Ketteler, A. Ferreira, A. Covic, B. Rutkowski, D. Memmos, W. J. Bos, V. Teplan, J. Nagy, C. Tielemans, D. Verbeelen, D. Goldsmith, R. Kramar, P. Y. Martin, R. P. Wuthrich, D. Pavlovic, M. Benedik, J. E. Sanchez, P. Martinez-Camblor, M. Naves-Diaz, J. J. Carrero, C. Zoccali. Use of phosphate-binding agents is associated with a lower risk of mortality. Kidney Int 84: 998-1008; 2013. IF.: 8.395 Quartile: Q1(D1)
  • I. Cabezas-Rodriguez, J. J. Carrero, C. Zoccali, A. R. Qureshi, M. Ketteler, J. Floege, G. London, F. Locatelli, J. L. Gorriz, B. Rutkowski, D. Memmos, A. Ferreira, A. Covic, V. Teplan, W. J. Bos, R. Kramar, D. Pavlovic, D. Goldsmith, J. Nagy, M. Benedik, D. Verbeelen, C. Tielemans, R. P. Wuthrich, P. Y. Martin, C. Martinez-Salgado, J. L. Fernandez-Martin, J. B. Cannata-Andia. Influence of body mass index on the association of weight changes with mortality in hemodialysis patients. Clin J Am SocNephrol 8: 1725-1733; 2013. IF.: 4.780 Quartile: Q1

Book Chapters

Six in the last five years (five in English and one in Spanish):

  • Vitamin D and renal disease. Dusso A, Cannata-Andía JB. In Vitamin D 4th Edition, edited by David Feldman JWP, Roger Bouillon,Edward Giovannucci,David Goltzman,Martin Hewison 2017, pp 445-469.
  • Dietary phosphorus regulation of vitamin D metabolism in the kidney. Dusso A, Arcidiacono M, Carrillo-López N, Cannata-Andía JB. In Dietary Phosphorus – Health, Nutrition and Regulatory Aspects ( Chapter 11), edited by Calvo JUaMS, CRC Press is an imprint of Taylor & Francis Group, an Informa business, 2016.
  • Clinical and pre-clinical evidence of the skeletal/vascular adverse health effects of high dietary phospohorus. Cannata-Andía JB, Román-García P, Carrillo-López N, Dusso A. In Dietary Phosphorus – Health, Nutrition and Regulatory Aspects ( Chapter 3), edited by Calvo JUaMS, CRC Press is an imprint of Taylor & Francis Group, an Informa business, 2016.
  • Molecular Biology of Vitamin D: Genomic and Nongenomic Actions of Vitamin D in Chronic Kidney Disease. Dusso A. In Vitamin D in Chronic Kidney Disease, edited by Ureña Torres P. CM, Vervloet M. , Springer, Cham, 2016, pp 51-74.
  • Mineral and bone disorders in CKD. Cannata-Andía JB, N. C-L-, Rodríguez-García M, Torregrosa, V. In Management of Chronic Kidney Disease, edited by Arici, Springer, 2014, pp 223-239.
  • Metabolismo Calcio-Fósforo y sus alteraciones. Cannata-Andía JB, Rodríguez García M. In Nefrología Clínica, edited by Hernando L, Arias M, Aljama P, Egido J, Lamas S, Praga M, Serón D, Editorial Médica Panamericana, 2013, pp 147-160.
Title Reference Number Duration Lead Researchers
Bone and mineral metabolism disorders associated with chronic kidney disease and diabetes. Clinical-Experimental Study FIS PI 17/00384 2018-2020 Jose Luis Fernández Martín
Cristina Alonso Montes
Barley β-glucans: an effective nutritional strategy for preventing the development of vascular calcification in chronic kidney disease FIS PI17/02181 2018-2020 Adriana Dusso
Minerva Rodríguez García
Studying microRNAs that regulate the RANK/RANKL/OPG pathway as predictors of vascular mineralisation (calcification) and bone demineralisation FI PI17/00715 2018-2020 Sara Panizo García
The effect of PTH and Klotho on bone, vascular and kidney disorders in experimental chronic kidney failure: the role of the Wnt pathway FIS PI16/00637 2017-2019 Natalia Carrillo López
Manuel Naves Díaz.
Membership of REDinREN (Renal Research Network) RD16/0009/0017 2016-2019 Jorge B. Cannata Andía
Consolidated Groups of the Principado de Asturias – FICYT (Foundation for the Promotion of Applied Scientific Research and Technology in Asturias) GRUPIN14-028 2015-2017 Jorge B. Cannata Andía
Synergy between vitamin D and β-glucans in mitigating vascular and immunological ageing in chronic kidney disease (CKD) FIS PI14/01452 2015-2017 Adriana Dusso
Bone and mineral metabolism disorders associated with chronic kidney disease and their treatment. European COSMOS Study FIS ICI14/00107 2015-2017 Jorge B. Cannata Andía
The role of intermediate filaments in vascular calcification associated with chronic kidney disease FIS PI14/00707 2015-2017 Jose Luis Fernández Martín
Minerva Rodríguez García
The importance of phosphorous, PTH and vitamin D receptor activators (VDRAs) in cardiac and kidney fibrosis and mineral metabolism disorders in chronic kidney disease FIS PI13/00014 2014-2016 Manuel L. Naves Díaz
The role of vitamin D receptor activators (VDRAs) in kidney fibrosis. Molecular mechanisms involved in vascular calcification: the role of oxidative stress and lamin A/C. (second year) IRSIN-FRIAT 2014 Jorge B. Cannata Andía
Identification and verification of a differential expression profile for circulating microRNAs, for the early diagnosis and prediction of chronic kidney disease evolution FIS PI13/00497 2014-2016 Isabel Rodríguez García
Membership of REDinREN RD12/0021/0023 2013-2016 Jorge B. Cannata Andía
Molecular mechanisms involved in vascular calcification: the role of oxidative stress and lamin A/C. FIS PI 11/00667 2012-2014 José Luis Fernández Martín

 

Title PhD Student Supervisors Organisation Date of Viva
Identification of markers for early detection of vascular calcification risk: a study of extracellular matrix proteins (2017) Noelia Martín Fernández María Isabel Rodríguez García
Jorge Benito Cannata Andía
Universidad de Oviedo 20-6-2017
Calcification of the aortic valve: a study of microRNAs and their possible clinical application Ana María Barral Varela Isabel Rodríguez García
Juan Carlos Llosa Cortina
Universidad de Oviedo 6-2-2015
Extracellular matrix protein polymorphism and differential expression profile in vascular calcification Diego Tuñón Le Poultel María Isabel Rodríguez García
Manuel Naves Díaz
Universidad de Oviedo 13-12-2013

Collaborations with external groups

  • The Bone Metabolism group leads, sponsors and manages the design and realisation of the European COSMOS Study (Current Management Of Secondary Hyperparathyroidism: a Multicentre Observational Study). This is a large-scale study, involving 20 European countries and 6797 patients, with a follow-up period of three years.
  • Collaboration with the University of Amsterdam, Cardiovascular Division, VU Medical Center. Title of collaboration: The central role of the cardiomyocyte exosomes resulting from cardiac hypertrophy in chronic kidney disease (Drs Marc Vervloet and Diederik Kuster; September – December 2018).
  • Member of the Executive Committee of the EUROD (European Renal Osteodystrophy): a project with UC Louvain and ERA-EDTA (European Renal Association – European Dialysis and Transplant Association) recording vertebral fractures and bone biopsies in Europe in chronic kidney disease patients.
  • Collaboration with the Cardiovascular Division, King’s College London (UK), Catherine Shanahan, (Vascular calcification).
  • Collaboration with the Department of Morphology, Surgery and Experimental Medicine and the LTTA Centre, Università degli Studi di Ferrara, Italy (histological characterisation of parathyroid disorders in the progression of kidney damage using a transgenic mouse that does not develop secondary hyperparathyroidism).
  • Collaboration with the Kidney Division, Karolinska Institutet, Stockholm, Sweden (cardiovascular disorders in peritoneal dialysis, vascular stiffness, calcification).
  • Collaboration on the NEFRONA Project genetic studies: “Observational, prospective and multicentre study to establish an atherosclerosis assessment model and its value for predicting cardiovascular events in chronic kidney disease patients in Spain” (Hospital Universitari Arnau de Vilanova, Lleida).
  • Collaboration with the Fundación Jiménez Díaz of Madrid (functional study of the gremlin protein).
  • Collaboration with the Universidad de Alcalá de Henares (studies of oxidative stress markers in vascular calcification processes).
  • Collaboration with the Universidad de Salamanca (a study of kidney fibrosis in an animal model with chronic kidney failure and parathyroidectomy).

Collaborations with Biotechnology Companies and Private Institutions (Spin-off)

  • Collaboration agreement with the ENTRECHEM SL biotechnology company (analysis of the effects of mithramycin analogues in an in vitro vascular calcification model).
  • Collaboration with HEALTHSENS (member of the Scientific Advisory Board).