Research Divisions

Translational Research on Infectious Diseases

Group LeaderLocation and ContactMembersLines of ResearchNotable PublicationsProjectsPhD Theses

Víctor Asensi Álvarez

  • Clinical Professor of Medicine, Universidad de Oviedo
  • Infectious Diseases Unit, Hospital Universitario Central de Asturias (HUCA)

Hospital Universitario Central de Asturias (HUCA)

Avenida Hospital Universitario s/n

33011 Oviedo, Spain.

NamePositionOrganisation
Víctor Asensi ÁlvarezClinical Professor of Medicine
Internal Medicine / Infectious Diseases
Universidad de Oviedo
HUCA
José Antonio Carton Sánchez Clinical Professor of Medicine
Head of the Internal Medicine / Infectious Diseases Section
Universidad de Oviedo
HUCA
José Maria Asensi ÁlvarezAssociate Lecturer in Medicine
Specialist Health Professional (FEA) in Neurology
Universidad de Oviedo
Hospital de Cabueñes
María Guadalupe Martín Ortiz FEA in ICUHUCA
Tomás Suárez Zarracina FEA in Internal MedicineHUCA
Maria Belén de la Fuente García FEA in Internal Medicine / Infectious DiseasesHospital de Cabueñes
Eulalia Valle Garay Tenured LecturerUniversidad de Oviedo
Angel Hugo Montes Hernández Assistant LecturerUniversidad de Oviedo
Laura Pérez IsPhD Student
María Eugenia Rivas CarmenadoClinician Scientist
  • The pathogenesis of osteomyelitis
  • The pathogenesis of sepsis
  • HIV infection and associated metabolic alterations
  • Cellular and humoural immunity
  • Treatment of hepatitis B and C in patients coinfected with HIV
  • VALLE-GARAY, E.; MONTES, A.H.; CORTE, J.R.; MEANA, A.; FIERER, J.; ASENSI, V.: tPA Alu (I/D) polymorphism associates with bacterial Osteomyelitis. J Infect Dis 2013; 208: 218-223.
  • SANTOS, DE LOS, I.; GÓMEZ-BERROCAL, A.; VALENCIA, E.; ASENSI, V.; GIJÓN, ; MORENO, V.; VERGAS, J.; BERNARDINO, I.: Efficacy and tolerability of darunavir/ritonavir in combination with abacavir/lamivudine. An option in selected HIV-infected patients. HIV Clin Trials 2013; 14: 254-260.
  • GUTIÉRREZ, F.; GARCÍA, L.; PADILLA, S.; ÁLVAREZ, D.; MORENO, S.; NAVARRO, G.; GÓMEZ-SIRVENT, J.; VIDAL, F.; ASENSI, V.; MASIÁ, M.; CORIS: Risk of clinically significant depression in HIV-infected patients: effect of antiretroviral drugs. HIV Med 2014; 15:213-223.
  • VILADÉS, C.; ESCOTÉ, X.; LÓPEZ-DUPLA, M.; MARTÍNEZ, E.; DOMINGO, P.; ASENSI, V.; LEAL, M.; PERAIRE, J.; INZA, M.I.; ARNEDO, M.; GUTIÉRREZ, M.; VALLE-GARAY, E.; FERRANDO-MARTÍNEZ, S.; OLONA, M.; ALBA, V.; SIRVENT, J.J.; GATELL, J.M.; VIDAL, F. on behalf of the HALS Study Group: Involvement of the LPS-LPB-CD14-MD2-TLR4 inflammation pathway in HIV-1/HAART-associated lipodystrophy syndrome (HALS). J Antimicrob Chemother 2014; 69: 1653-1659.
  • MARTÍNEZ-ZAPICO, A.; ASENSI, V.; FUENTES, N.; FONOLLA, M.; RODRÍGUEZ, M.; CÁRCABA, V.; CARTON, J.A.: Immune reconstitution inflammatory syndromeunmasking endophtalmic, lymphadenopathic, and neuromeningeal cryptococcosis in an HIV-infected patient starting highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2014; 30: 434-435.
  • MARTÍN, G.; ASENSI, V.; MONTES, A.H.; COLLAZOS, J.; ÁLVAREZ, V.; CARTON, A.; TABOADA, F.; VALLE-GARAY, E.: Role of plasma matrixmetalloproteases (MMPs) and their polymorphisms (SNPs) in sepsis development and outcome in ICU patients. Sci Rep 2014; May 16; 4: 5002.
  • PODZAMCZER, D.; IMAZ, A.; PÉREZ, I.; VICIANA, P.; VALENCIA, E.; CURTO, J.; MARTÍN, T.; CASTAÑO, M.; ROJAS, J.; ESPINOSA, N.; MORENO, V.; ASENSI, V.; IRIBARREN, J.A.; CLOTET, B.; FORCE, L.; BACHILLER, P.; KNOBEL, H.; LÓPEZ BERNALDO DE QUIRÓS, J.C.; BLANCO,J.R.; ROZAS, N.; VERGAS, J.; OCAMPO, A.; CAMACHO, A.; FLORES, J.; GÓMEZ-SIRVENT,J.L. on behalf of the KIDAR Study Group: Abacavir/lamivudine plus darunavir/ritonavir in routine clinical practice: a multicentre experience in antirretroviral therapy-naive and -experienced patients. J Antimicrob Chemother 2014;69: 2536-2540.
  • PERAIRE, J.; LÓPEZ-DUPLA, M.; ALBA, V.; BELTRÁN-DEBON, R.; MARTÍNEZ, E.; DOMINGO, P.; ASENSI, V.; LEAL, M.; VILADÉS, C.; INZA, M.I.; ESCOTÉ, X.; ARNEDO, M.; MATEO, G.; VALLE-GARAY, E.; FERRANDO-MARTINEZ, S.; VELOSO, S.; VENDRELL, J.; GATELL, J.M.; HIV-1 LIPODYSTROPHY STUDY GROUP: HIV/antiretroviral therapy-related Lipodystrophy Syndrome (HALS) is associated with higher RBP4 and lower omentin in plasma. Clin Microbiol Infect 2015; 21: 711.e1-8.
  • ECHEVARRÍA, A.; MORO-GARCÍA, M.A.; ASENSI, V.; CARTON, J.A.; LÓPEZLARREA,; ALONSO-ARIAS, R.: CD4 CD4+CD28null T lymphocytes resemble CD8+CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIVinfected patients. J Leukoc Biol. 2015; 98: 373-284. COLLAZOS, J.; ASENSI, V.; MARTÍN, G.; MONTES, A.H; SUÁREZ-ZARRACINA, T; VALLE-GARAY, E.: The effect of gender and genetic polymorphisms on MMPs and TIMPs plasma levels in different infectious and non-infectious Clin Exp Immunol 2015; 182; 213-219.
  • ASENSI, V.; COLLAZOS, J.; VALLE-GARAY, E.: ≪Can antiretroviral therapy be tailored to each human immunodeficiency virus-infected individual? Role of pharmacogenomics. World J Virol 2015; 4: 169-177.
  • ROJAS, C.; LONCA, M.; IMAZ, A.; ESTRADA, V.; ASENSI, V.; MIRALLES, C.; DOMINGO, P.; MONTERO, M.; DEL RÍO, L.; FONTDEVILA, J.; PÉREZ, L.; CRUCETA, A.; GATELL, J.M.; ARNEDO, M.; MARTÍNEZ, E.: Improvement of lipoatrophy by switching from efavirenz to lopinavir/ritonavir. HIV Med 2016; 17: 340-349.
  • TORRECILLA GARCÍA,E.; YEBRA SANZ, G.; LLÁCER-DELICADO, T.; RUBIO GARCÏA, ; GONZÁLEZ-GARCÍA, J.; GARCÍA GARCÍA, F.; LÓPEZ-ALDEGUER, J.; ASENSI ÁLVAREZ, V.; HOLGUÍN FERNÁNDEZ, A.; COHORT OF THE SPANISH AIDS RESEARCH NETWORK (CORIS): Clinical, epidemiological and treatment failure data among HIV-1 non-B-infected patients in the Spanish AIDS Research Network cohort. Enf Infecc Microbiol Clin 2015; 33: 40.e1-40.e16.
  • COLLAZOS, J.; VALLE-GARAY, E.; CARTON, J.A.; MONTES, A.H.; SUÁREZ ZARRACINA,; DE LA FUENTE, B.; ASENSI, V.: Factors associated with long-term CD4 cell recovery in HIV-infected patients under successful antiretroviral therapy. HIV Med 2016; 17: 532-541.
  • SOBRINO-VEGAS, P.; MORENO, S.; RUBIO, R.; VICIANA, P.; BERNARDINO, J.I; BLANCO, J.R; BERNAL, E.; ASENSI, V.; PULIDO, F.; DEL AMO, J.; HERNANDO, V.; CORIS: Impact of late presentation of HIV infection on short-, midand long-term mortality and causes of death in a multicenter national cohort: 2004-2013≫. J Infect. 2016; 587-596.
  • ALEJOS, B.; HERNANDO, V.; IRIBARREN; I.; GONZÁLEZ-GARCÍA, J.; HERNANDO,; SANTOS, J.; ASENSI, V.; GÓMEZ-BERROCAL, A.; DEL AMO, J.; JARRÍN, I.; CORIS (COHORT OF THE SPANISH NETWORK ON HIVAIDS RESEARCH). Overall and cause-specific excess mortality in HIV-positive persons compared with the general population: Role of HCV coinfection≫. Medicine (Baltimore). 2016; 95:e4727.
  • Collazos J, Valle-Garay E, Suárez-Zarracina T, Montes AH, Cartón JA, Asensi V. Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients. World J Virol. 2017 May 12;6(2):36-45. doi: 10.5501/wjv.v6.i2.36.
  • Perez-Molina JA, Rubio R, Rivero A, Pasquau J, Suárez-Lozano I, Riera M, Estébanez M, Palacios R, Sanz-Moreno J, Troya J, Mariño A, Antela A, Navarro J, Esteban H, Moreno S; GeSIDA 7011 Study Group.Simplification to dual therapy (atazanavir/ritonavir + lamivudine) versus standard triple therapy (atazanavir/ritonavir + two nucleos(t)ides) in virologically stable patients on antiretroviral therapy: 96 week results from an open-label, non-inferiority, randomized clinical trial (SALT study). J Antimicrob Chemother. 2017 Jan;72(1):246-253.
Principal InvestigatorTitleFunding BodyReference NoDurationAmount
Victor Asensi AlvarezThe correlation between extracellular matrix metalloproteinases, serum lipids and changes in liver fibrosis in patients coinfected with HIV / GT1 HCV and treated with two AAD regimensISCIII (Instituto de Salud Carlos III) - AES (Strategic Action in Health Research)PI16/019992017-2019€84,700
Victor Asensi AlvarezExtracellular matrix metalloproteinases (MMPs) and their relationship to HIV infection.Consejeria de Economia y EmpleoSV-PA-13-ECOEMP-572013-2015€47,068.36

 

SupervisorsTitlePhD StudentOrganisationDate of Viva
Victor Asensi AlvarezF. Taboada Costa

E. Valle Garay

Polymorphism of cytokines, nitric oxide synthases and “toll-like” receptors in sepsisGuadalupe MartinUniversidad de Oviedo31/1/2015