Research Divisions

Translational Immunology

Group LeaderLocation and ContactMembersLines of ResearchNotable PublicationsProjectsPhD ThesesPatents and TrademarksNews

Carlos López Larrea

  • Head of the Immunology Department, Hospital Universitario Central de Asturias (HUCA)
  • Professor of Immunology, Universidad de Oviedo

Hospital Universitario Central de Asturias (HUCA)

Avenida Hospital Universitario s/n

33011 Oviedo, Spain.

Telephone: +34 985108000 ext. 37587

E-mail: inmuno@hca.es

NamePositionOrganisation
Carlos López LarreaImmunology DepartmentHUCA
Beatriz Suárez ÁlvarezMiguel Servet ContractHUCA-ISPA
José Ramón Vidal CastiñeiraSpecialist Health Professional (FEA), Immunology DepartmentHUCA
Ramón Rodriguez LópezJuan de la Cierva ContractHUCA-ISPA
Aroa Baragaño RanerosPostdoctoral ResearcherISPA
Paula Diaz BulnesREDINREN (Renal Research Network) ContractISPA
Jesús Martínez BorraFEA, Immunology DepartmentHUCA
Antonio López VázquezFEA, Immunology DepartmentHUCA
Carmen Diaz CorteFEA, Nephrology DepartmentHUCA
Ruben Queiro SilvaFEA, Rheumatology DepartmentHUCA
Juan Carlos Torre Alonso
María Del Pilar Palomo Moraleda
Jose Joaquin Bande Fernandez
Soledad González Muñiz
Carlos Álvarez Fernandez
Manuel Rodríguez García
Viviana Corte Iglesias
Ana Cristina Andrade Lopez
Ana Perez Suarez
Aida Bernardo FlórezPhD studentUniversidad de Oviedo
Cristian Ruiz BernetMaster studentUniversidad de Oviedo

 

Monitoring Immune Response in Transplants

Defining a risk and/or immunological tolerance profile in transplant patients (kidney, heart, liver and haematopoietic stem cell transplants) able to predict chronic and acute rejection.

Epigenetic mechanisms involved in immune system differentiation and pathological implications

Characterisation of the epigenome (DNA methylation and histone modification) of the various cellular compartments of the immune system and of haematopoietic stem cells.

Identification of genetic factors associated with spondyloarthropathies and rheumatological diseases

Genomic analysis through large-scale sequencing of functional genes associated with spondyloarthropathies (SpA).

Regulation of expression of the NKG2D receptor and its ligands (MICA, MICB and ULBPs).-

Studying the mechanisms of genetic and epigenetic regulation, as well as the release of NKG2D ligands and their receptor during immunological recognition of haematological malignancies in kidney diseases.

  • López-Vázquez A, Mozo L, Alonso-Arias R, Suárez-Álvarez B, Vidal-Castiñeira JR, Arranz E, Volta U, Bousoño C, López-Hoyos M, Rodrigo L, López-Larrea C. Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients. BMC Med. 2014;12(1):34.
  • Moro-García MA, Echeverría A, Galán-Artímez MC, Suárez-García FM, Solano-Jaurrieta JJ, Avanzas-Fernández P, Díaz-Molina B, Lambert JL, López-Larrea C, Morís de la Tassa C, Alonso-Arias R. Immunosenescence and inflammation characterize chronic heart failure patients with more advanced disease. Int J Cardiol. 2014; 174(3):590-9.
  • Baragaño Raneros A, Suarez-Álvarez B, López-Larrea C. Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention. Oncoimmunology. 2014 Apr 25;3:e28497.
  • Vidal-Castiñeira JR, López-Vázquez A, Martínez-Borra J, Martínez-Camblor P, Prieto J, López-Rodríguez R, Sanz-Cameno P, De la Vega J, Rodrigo L, Perez-Lopez R, Perez-Alvarez R, Lopez-Larrea C. Diversity of killer cell immunoglobulin-like receptor (KIR) genotypes and KIR2DL2/3 variants in HCV treatment outcome. PLoS One 2014; 9(6):e99426.
  • Huergo-Zapico L, Acebes-Huerta A, Gonzalez-Rodriguez AP, Contesti J, Gonzalez-García E, Payer AR, Villa-Alvarez M, Fernández-Guizán A, López-Soto A, Gonzalez S. Expansion of NK Cells and Reduction of NKG2D Expression in Chronic Lymphocytic Leukemia. Correlation with Progressive Disease. PLoS One. 2014 Oct 6;9(10):e108326.
  • Serrano-Pertierra E, Cernuda-Morollón E, Brdička T, Hoøejši V, López-Larrea C. L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration. J Leukoc Biol. 2014 Sep;96(3):437-45.
  • Moro-García MA, Fernández-García B, Echeverría A, Rodríguez-Alonso M, Suárez-García FM, Solano-Jaurrieta JJ, López-Larrea C, Alonso-Arias R. Frequent participation in high volume exercise throughout life is associated with a more differentiated adaptive immune response. Brain Behav Immun. 2014 Jul;39:61-74.
  • Serrano-Pertierra E, Cernuda-Morollón E, López-Larrea C. NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp. J Leukoc Biol. 2014 Mar;95(3):487-95.
  • Urdinguio RG, Fernandez AF, Moncada-Pazos A, Huidobro C, Rodriguez RM, Ferrero C, Martinez-Camblor P, Obaya AJ, Bernal T, Parra-Blanco A, Rodrigo L, Santacana M, Matias-Guiu X, Soldevilla B, Dominguez G, Bonilla F, Cal S, Lopez-Otin C, Fraga MF. Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. Cancer Res. 2013 Jan 1;73(1):395-405
  • Rodriguez RM, Suarez-Alvarez B, Salvanés R, Muro M, Martínez-Camblor P, Colado E, Sánchez MA, Díaz MG, Fernandez AF, Fraga MF, Lopez-Larrea C. Correction: DNA Methylation Dynamics in Blood after Hematopoietic Cell Transplant. PLoS One. 2013; 8(2):e56931
  • Suárez-Álvarez B, Baragaño Raneros A, Ortega F, López-Larrea C. Epigenetic modulation of the immune function: a potential target for tolerance. Epigenetics. 2013;8(7):694-702.
  • Alonso Arias R, Moro-García MA, Echeverría A, Solano-Jaurrieta JJ, Suárez-García FM, López-Larrea C. Intensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system. J Virol. 2013 Apr;87(8):4486-95.
  • Fernández-Sánchez A, Baragaño Raneros A, Carvajal Palao R, Sanz AB, Ortiz A, Ortega F, Suárez-Álvarez B, López-Larrea C. DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8+ T and NK cells. Epigenetics. 2013;8(1):66-78.
  • Queiro R, Tejón P, Coto P, Alonso S, Alperi M, Sarasqueta C, González S, Martínez-Borra J, López-Larrea C, Ballina J. Clinical differences between men and women with psoriatic arthritis: relevance of the analysis of genes and polymorphisms in the major histocompatibility complex region and of the age at onset of psoriasis. Clin Dev Immunol. 2013;2013:482691.
  • López-Soto A, Gonzalez S, López-Larrea C, Kroemer G.Immunosurveillance of Malignant Cells with Complex Karyotypes.Trends Cell Biol. 2017 Dec;27(12):880-884.
  • López-Rodríguez R, Hernández-Bartolomé Á, Borque MJ, Rodríguez-Muñoz Y, Martín-Vílchez S, García-Buey L, González-Moreno L, Real-Martínez Y, Muñoz de Rueda P, Salmerón J, Vidal-Castiñeira JR, López-Larrea C, Rodrigo L, Moreno-Otero R, Sanz-Cameno P.Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C.PLoS One. 2017 Jul 12;12(7):e0180927.
  • Suarez-Alvarez B, Rodriguez RM, Ruiz-Ortega M, Lopez-Larrea C.BET Proteins: An Approach to Future Therapies in Transplantation. Am J Transplant. 2017 Sep;17(9):2254-2262.
  • Suarez-Álvarez B, Rodríguez RM, Schlangen K, Raneros AB, Márquez-Kisinousky L, Fernández AF, Díaz-Corte C, Aransay AM, López-Larrea C.Phenotypic characteristics of aged CD4+ CD28null T lymphocytes are determined by changes in the whole-genome DNA methylation pattern. Aging Cell. 2017 Apr;16(2):293-303.
  • Rodriguez RM, Suarez-Alvarez B, Lavín JL, Mosén-Ansorena D, Baragaño Raneros A, Márquez-Kisinousky L, Aransay AM, Lopez-Larrea C.Epigenetic Networks Regulate the Transcriptional Program in Memory and Terminally Differentiated CD8+ T Cells. J Immunol. 2017 Jan 15;198(2):937-949.
  • Suarez-Alvarez B, Morgado-Pascual JL, Rayego-Mateos S, Rodriguez RM, Rodrigues-Diez R, Cannata-Ortiz P, Sanz AB, Egido J, Tharaux PL, Ortiz A, Lopez-Larrea C, Ruiz-Ortega M.Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage. J Am Soc Nephrol. 2017 Feb;28(2):504-519.
Principal InvestigatorTitleFunding BodyReference NoDurationAmount
Carlos López LarreaEpigenetic modulation of immunological tolerance: development of new therapeutic approaches in kidney transplantationInstituto de Salud Carlos IIIPI16/013182017-2019€230,202.50 .
Beatriz Suárez ÁlvarezEpigenetic regulation of the inflammatory processes associated with chronic kidney damage: identification of new therapeutic targetsInstituto de Salud Carlos IIIPI17/012442018-2020€62,920
Carlos López LarreaTranslational Immunology Research GroupFICYT (Foundation for the Promotion of Applied Scientific Research and Technology in Asturias). Principado de AsturiasGRUPIN14-0302014-2017€238,000
Carlos López LarreaREDINREN Renal Research Network RD16/0009Instituto de Salud Carlos IIIRD16/0009/00202017-2021€105,435

 

SupervisorsTitlePhD StudentOrganisationDate of Viva
Carlos López LarreaBeatriz Suarez ÁlvarezEpigenetic regulation of NKG2D ligands: therapeutic implications in acute myeloid leukaemiaAroa Baragaño RanerosUniversidad de Oviedo10/07/2017

 

Healthsens SL, spin-off company.

Creation Date: 2009

Company created to develop, produce and market electrochemical sensors for the (early) detection and/or monitoring of biomarkers associated with diseases that are highly prevalent in the population. Carlos López Larrea is a co-founder and member of the Board of Directors of HealthSens