César Morís de la Tassa

• Tenured Lecturer in the Medicine Department, Universidad de Oviedo, Cardiology specialist.
• Coordinator of the Heart Clinical Management Division of the Hospital Universitario Central de Asturias (HUCA). Position: Department Head.

Arrhythmias and arrhythmogenic mechanisms

1. Characterisation of the mechanisms for the maintenance of persistent human atrial fibrillation and their response to therapeutic intervention through radiofrequency ablation
2. Determinism in human ventricular fibrillation. Periodic high-frequency centrifugal activity connected to the areas of greatest electrophysiological heterogeneity in the ventricular myocardium.
3. Electrocardiographic quantification using non-linear signal analysis methods: diagnostic and predictive value for Brugada Syndrome.
4. Treatment of the bipolar endocardial signal during atrial fibrillation and analysis of how its behaviour changes over time with each progressive stage of the disease in humans.
5. Correction of the QT interval when severe ventricular depolarisation disorders are present.
6. Mechanisms and psychometric characterisation of patients with supraventricular tachycardia.

Valvular pathology

1. Valvular prosthesis - patient mismatch.
2. Percutaneous treatment of aortic valve disease.
3. Markers of predisposition to aortic pathology.

Myocardial lesions

1. Treatment and progress after heart transplant.
2. The impact of resynchronisation on cost and the quality of life of heart failure patients.

Immunology of cardiovascular diseases

1. Alterations in t-lymphocytes in cardiovascular pathology.
2. The impact of CMV infection on cardiovascular pathology.

• Calvo D, Rubín J, Pérez D, Jalife J. Spectral analysis of electrograms in a substrate modified by radiofrequency ablation reveals similarities between organized and disorganized atrial rhythms. Heart Rhythm. 2014;11:2306–2309.
• Calvo D, Atienza F, Saiz J, Martínez L, Ávila P, Rubín J, Herreros B, Arenal Á, García-Fernández J, Ferrer A, Sebastián R, Martínez-Camblor P, Jalife J, Berenfeld O. Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate. Circ Arrhythm Electrophysiol. 2015;8:1133-1143.
• Calvo D, Rubín JM, Pérez D, Gómez J, Flórez JP, Avanzas P, García-Ruíz JM, de la Hera JM, Reguero J, Coto E, Morís C. Time-dependent responses to provocative testing with flecainide in the diagnosis of Brugada syndrome. Heart Rhythm. 2015;12:350-357.
• Calvo D, Ávila P, García-Fernández FJ, Pachón M, Bravo L, Eidelman G, Hernández J, Miracle ÁL, Rubín J, Pérez D, Arenal Á, Atienza F, Jimenez-Candil J, Arias MÁ, Datino T, Martínez-Camblor P, Gonzalez-Torrecilla E, Almendral J. Differential Responses of the Septal Ventricle and the Atrial Signals During Ongoing Entrainment: A Method to Differentiate Orthodromic Reciprocating Tachycardia Using Septal Accessory Pathways From Atypical Atrioventricular Nodal Reentry. Circ Arrhythm Electrophysiol. 2015;8:1201-1209.
• David Calvo, José Jalife. Mechanoelectric Feedback in the Ischemic Myocardium: An Interplay That Modulates Susceptibility to Fibrillation. Revista Española de cardiología. 2013. Mar;66(3):168-170.
• David Calvo, Flórez JP, Valverde I, Rubín J, Pérez D, Vasserot MG, Rodríguez-Reguero J, Avanzas P, de la Hera JM, Gómez J, Coto E, Martínez-Camblor P, Morís C. Surveillance after Cardiac Arrest in patients with Brugada Syndrome without an implantable defibrillator: An alarm effect of the previous Syncope. Int J Cardiol. 2016 May 13;218:69-74.
• Riobello C, Gómez J, Gil-Peña H, Tranche S, Reguero JR, de la Hera JM, Delgado E, Calvo D, Morís C, Santos F, Coto-Segura P, Iglesias S, Alonso B, Alvarez V, Coto E. KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort. Mol Cell Endocrinol. 2016 May 15;427:86-91.
• Salgado R, Martín J, Martínez J, Alzueta J, Viñolas X, Fernández J, Molina M, Pérez L, Calvo D, García J. Small-Caliber Lead Failure After Generator Exchange. J Cardiovasc Electrophysiol. 2016;27(7):846-50.
• Rodrigo M, Climent AM, Liberos A, Calvo D, Fernández-Avilés F, Berenfeld O, Atienza F, Guillem MS. Identification of Dominant Excitation Patterns and Sources of Atrial Fibrillation by Causality Analysis. Ann Biomed Eng. 2016;44(8):2364-76.
• Loughlin G, Romaniega TD, Garcia-Fernandez J, Calvo D, Salgado R, Alonso A, Li X, Arenal A, González-Torrecilla E, Atienza F, Fernández-Avilés F. Immediate post-procedure bridging with unfractioned heparin versus low molecular weight heparin in patients undergoing radiofrequency ablation for atrial fibrillation with an interrupted oral anticoagulation strategy. J Interv Card Electrophysiol. 2016;45(2):149-58.
• Ruiz-Salas A, Datino T, Peña-Hernández J, Calvo D, Alzueta J. Inappropriate shock due to late dislocation of electrode. Int J Cardiol. 2015 Nov 15;199:229-31.
• Hernandez-Vaquero D, Garcia JM, Diaz R, Calvo D, Khalpey Z, Hernández E, Rodriguez V, Morís C, Llosa JC. Moderate patient-prosthesis mismatch predicts cardiac events and advanced functional class in young and middle-aged patients undergoing surgery due to severe aortic stenosis. J Card Surg. 2014;29:127-33.
• Pascual I, Moris C, Avanzas P. Beta-Blockers and Calcium Channel Blockers: First Line Agents. Cardiovasc Drugs Ther. 2016;30:357-65.
• Pascual I, Muñoz-García AJ, López-Otero D, Avanzas P, Jimenez-Navarro MF, Cid-Alvarez B, Del Valle R, Alonso-Briales JH, Ocaranza-Sanchez R, Hernández JM,Trillo-Nouche R, Morís C. Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up. J Geriatr Cardiol. 2015;12:340-5.
• García-Álvarez A, Pereda D, García-Lunar I, Sanz-Rosa D, Fernández-Jiménez R, García-Prieto J, Nuño-Ayala M, Sierra F, Santiago E, Sandoval E, Campelos P, Agüero J, Pizarro G, Peinado VI, Fernández-Friera L, García-Ruiz JM, Barberá JA, Castellá M, Sabaté M, Fuster V, Ibañez B. Beta-3 adrenergic agonists reduce pulmonary vascular resistance and improve right ventricular performance in a porcine model of chronic pulmonary hypertension. Basic Res Cardiol. 2016 Jul;111(4):49.
• López-Melgar B, Fernández-Friera L, Sánchez-González J, Vilchez JP, Cecconi A, Mateo J, Peñalvo JL, Oliva B, García-Ruiz JM, Kauffman S, Jiménez-Borreguero LJ, Ruiz-Cabello J, Fernández-Ortiz A, Ibáñez B, Fuster V. Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method. Atherosclerosis. 2016 May;248:230-7
• García-Ruiz JM, Fernández-Jiménez R, García-Alvarez A, Pizarro G, Galán-Arriola C, Fernández-Friera L, Mateos A, Nuno-Ayala M, Aguero J, Sánchez-González J, García-Prieto J, López-Melgar B, Martínez-Tenorio P, López-Martín GJ, Macías A, Pérez-Asenjo B, Cabrera JA, Fernández-Ortiz A, Fuster V, Ibáñez B. Impact of the timing of metoprolol administration during ongoing STEMI on infarct size and ventricular function: a METOCARD-CNIC trial substudy with an experimental validation. J Am Coll Cardiol. 2016 May 10;67(18):2093-104.
• Hausenloy DJ, Kharbanda R, Rahbek Schmidt M, Møller UK, Ravkilde J, Okkels Jensen L, Engstrøm T, Garcia Ruiz JM, Radovanovic N, Christensen EF, Sørensen HT, Ramlall M, Bulluck H, Evans R, Nicholas J, Knight R, Clayton T, Yellon DM, Bøtker HE. Effect of remote ischaemic conditioning on clinical outcomes in patients presenting with an ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur Heart J. 2015;36(29):1846-8.
• Díaz-Molina B, Lambert JL, Víchez FG, Cadenas F, Bernardo MJ, Velasco E, Martín M, Morís C. Quality of life according to urgency status in de novo heart transplant recipients. Transplantation Proceedings 2016; 48: 3024-6.
• Fernandez Alvarez R, Rubinos Cuadrado G, Alonso Arias R, Cascon Hernandez JA, Palomo Antequera B, Iscar Urrutia M, Casan Clara P. Snoring as a Determinant Factor of Oxidative Stress in the Airway of Patients with Obstructive Sleep Apnea. Lung. 2016; 194 (3): 469-73.
• Moro-García MA, López Iglesias F, Avanzas P, Echeverría A, López-Larrea C, Morís de la Tassa C, Alonso-Arias R. Disease complexity in acute coronary syndrome is related to the patient's immunological status. Int J Cardiol. 2015; 189: 115-23.
• Pascual I, Carro A, Avanzas P, Hernández-Vaquero D, Díaz R, Rozado J, Lorca R, Martín M, Silva J, Morís C. Vascular approaches for transcatheter aortic valve implantation. J Thorac Dis. 2017 May;9(Suppl 6):S478-S487.
• Hernandez-Vaquero D, Diaz R, Pascual I, Rozado J, De la Hera JM, Leon V, Avanzas P, Martín M, García-Iglesias D, Calvo D, Silva J, Moris C. The Prevalence of Patient-Prosthesis Mismatch Can Be Reduced Using the Trifecta Aortic Prosthesis. Ann Thorac Surg. 2018 Jan;105(1):144-151.
• Díaz R, Hernández-Vaquero D, Silva J, Pascual I, de la Hera JM, León V, Martín M, Barriales V, Colunga S, Del Valle R, Morís C. Real Structural Valve Deterioration of the Mitroflow Aortic Prosthesis: Competing Risk Analysis. Rev Esp Cardiol (Engl Ed). 2017 Dec;70(12):1074-1081.
• García-Prieto J, Villena-Gutiérrez R, Gómez M, Bernardo E, Pun-García A, García-Lunar I, Crainiciuc G, Fernández-Jiménez R, Sreeramkumar V, Bourio-Martínez R, García-Ruiz JM, Del Valle AS, Sanz-Rosa D, Pizarro G, Fernández-Ortiz A, Hidalgo A, Fuster V, Ibanez B. Neutrophil stunning by metoprolol reduces infarct size. Nat Commun. 2017 Apr 18;8:14780.

SURTAVI - Clinical Trial Comparing Surgical Replacement and Transcatheter Aortic Valve Implantation.

• Sponsor: MEDTRONIC
• https://clinicaltrials.gov/ct2/show/NCT0158691
• Started in 2017

CoreValve™ Evolut R™ FORWARD Study (FORWARD)

• Sponsor: MEDTRONIC
• https://clinicaltrials.gov/ct2/show/NCT02592369
• Started in 2017

Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: A Multicentre Randomised Controlled Clinical Study. CONDI 2

• Sponsor: Danish Strategic Research Council.
• Completed in: 2014 – 2017

ATPCI Study -The Efficacy and Safety of Trimetazidine in Patients with Angina Pectoris having been Treated by Percutaneous Coronary Intervention.

• Sponsor: SERVIER.
• Completed in: 2014

GALILEO- Multicentre Study Comparing a Rivaroxaban-based Antithrombotic Strategy to an Antiplatelet-based Strategy after Transcatheter Aortic Valve Replacement (TAVR).

• Bayer HealthCare.
• Completed in: 2015

COMPLETE- Comparison of Complete vs Single Vessel Revascularisation after a Primary Angioplasty in Patients with Acute Coronary Syndrome

• Sponsor: Population Health Research Institute (PHRI).
• Completed in: 2015

Angiography Study of BioNIR Drug Eluting Stent System (NIREUS)

• Sponsor: Medinol
• https://clinicaltrials.gov/ct2/show/NCT01995500

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

• Sponsor: Sanofi
• Code: https://clinicaltrials.gov/ct2/show/NCT01663402

Oxygen carrying blood substitutes and their use as delivery vehicles

• Inventors: Borja Ibáñez Cabeza, José Manuel García-Ruiz, Jauma Agüero Ramon-Llin, Rodrigo Fernández-Jiménez, Valentín Fuster Carulla, Enrique Lara-Pezzi, Juan Antonio Bernal Rodríguez, Carlos Galán-Arriola, Andrés Pun García, Enda Joseph Clinton
• Ref No: EP17 382 040.8.
• First application: 28 January 2017