Research Divisions

Heart Disease

Group LeaderLocation and ContactMembersHistory of the GroupLines of ResearchNotable PublicationsProjectsPhD ThesesClinical TrialsPatents and TrademarksNews

César Morís de la Tassa

  • Tenured Lecturer in the Medicine Department, Universidad de Oviedo, Cardiology specialist.
  • Coordinator of the Heart Clinical Management Division of the Hospital Universitario Central de Asturias (HUCA). Position: Department Head.

Hospital Universitario Central de Asturias

Avenida de Roma s/n

33011 Oviedo, Spain.

Telephone: +34 985108000 Ext 39417


Name Organisation Activity Euraxess classification
Almendárez Lacayo, Marcel Gabriel SESPA Research/Clinical R1
Alonso Arias, Rebeca SESPA Research/Clinical/Teaching R3
Alonso Pérez, Manuel SESPA Research/Clinical R2
Alperi García, Alberto FINBA Research/Clinical R2
Álvarez Marcos, Francisco SESPA Research R2
Álvarez Velasco, Rut SESPA Research/Clinical R2
Antuña Álvarez, Paula SESPA Research/Clinical R2
Avanzas Fernández, Pablo SESPA Research/Clinical/Teaching R3
Ayesta López, Ana SESPA Research R2
Bueno García, Eva FINBA Research R1
Calvo Cuervo, David SESPA Research/Clinical/Teaching R3
Colunga Blanco, Santiago SESPA Research/Clinical/Teaching R2
del Río García, Álvaro FINBA Research R1
Díaz Méndez, Rocío SESPA Research/Clinical/Teaching R2
Díaz Molina, Beatriz SESPA Research/Clinical/Teaching R3
García Iglesias, Daniel SESPA Research/Clinical/Teaching R2
García Ruiz, José Manuel SESPA Research/Clinical/Teaching R2
García Torre, Alejandra FINBA Research R1
González Vasserot, Mar SESPA Research/Clinical/Teaching R2
Hernández-Vaquero Panizo, Daniel SESPA Research/Clinical/Teaching R3
Lambert Rodríguez, José Luis SESPA Research/Clinical/Teaching R3
Lorca Gutiérrez, Rebeca SESPA Research/Clinical R2
Lozano Martínez-Luengas, Íñigo Manuel SESPA Research/Clinical/Teaching R3
Martín Fernández, María SESPA Research/Clinical/Teaching R2
Mohamedi Munarriz, Yamina FINBA Research R2
Morís de la Tassa, César SESPA/Universidad de Oviedo Research/Clinical/Teaching R4
Pascual Calleja, Isaac SESPA Research/Clinical/Teaching R2
Pérez Díez, Diego SESPA Research/Clinical/Teaching R2
Rodríguez García, María Isabel FINBA Research R3
Rondán Murillo, Juan SESPA Research/Clinical/Teaching R2
Rozado Castaño, José SESPA Research/Clinical/Teaching R2
Rubín López, José Manuel SESPA Research/Clinical/Teaching R2
Samaniego Lampón, Beatriz SESPA Research/Clinical/Teaching R2
Valverde André, Irene SESPA Research/Clinical/Teaching R2
Vegas Valle, José Miguel SESPA Research/Clinical/Teaching R2
Moro García, Marco Antonio SESPA Research No classification

Arrhythmias and arrhythmogenic mechanisms

  1. Characterisation of the mechanisms for the maintenance of persistent human atrial fibrillation and their response to therapeutic intervention through radiofrequency ablation
  2. Determinism in human ventricular fibrillation. Periodic high-frequency centrifugal activity connected to the areas of greatest electrophysiological heterogeneity in the ventricular myocardium.
  3. Electrocardiographic quantification using non-linear signal analysis methods: diagnostic and predictive value for Brugada Syndrome.
  4. Treatment of the bipolar endocardial signal during atrial fibrillation and analysis of how its behaviour changes over time with each progressive stage of the disease in humans.
  5. Correction of the QT interval when severe ventricular depolarisation disorders are present.
  6. Mechanisms and psychometric characterisation of patients with supraventricular tachycardia.

Valvular pathology

  1. Valvular prosthesis - patient mismatch.
  2. Percutaneous treatment of aortic valve disease.
  3. Markers of predisposition to aortic pathology.

Myocardial lesions

  1. Treatment and progress after heart transplant.
  2. The impact of resynchronisation on cost and the quality of life of heart failure patients.

Immunology of cardiovascular diseases

  1. Alterations in t-lymphocytes in cardiovascular pathology.
  2. The impact of CMV infection on cardiovascular pathology.


  • Calvo D, Rubín J, Pérez D, Jalife J. Spectral analysis of electrograms in a substrate modified by radiofrequency ablation reveals similarities between organized and disorganized atrial rhythms. Heart Rhythm. 2014;11:2306–2309.
  • Calvo D, Atienza F, Saiz J, Martínez L, Ávila P, Rubín J, Herreros B, Arenal Á, García-Fernández J, Ferrer A, Sebastián R, Martínez-Camblor P, Jalife J, Berenfeld O. Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate. Circ Arrhythm Electrophysiol. 2015;8:1133-1143.
  • Calvo D, Rubín JM, Pérez D, Gómez J, Flórez JP, Avanzas P, García-Ruíz JM, de la Hera JM, Reguero J, Coto E, Morís C. Time-dependent responses to provocative testing with flecainide in the diagnosis of Brugada syndrome. Heart Rhythm. 2015;12:350-357.
  • Calvo D, Ávila P, García-Fernández FJ, Pachón M, Bravo L, Eidelman G, Hernández J, Miracle ÁL, Rubín J, Pérez D, Arenal Á, Atienza F, Jimenez-Candil J, Arias MÁ, Datino T, Martínez-Camblor P, Gonzalez-Torrecilla E, Almendral J. Differential Responses of the Septal Ventricle and the Atrial Signals During Ongoing Entrainment: A Method to Differentiate Orthodromic Reciprocating Tachycardia Using Septal Accessory Pathways From Atypical Atrioventricular Nodal Reentry. Circ Arrhythm Electrophysiol. 2015;8:1201-1209.
  • David Calvo, José Jalife. Mechanoelectric Feedback in the Ischemic Myocardium: An Interplay That Modulates Susceptibility to Fibrillation. Revista Española de cardiología. 2013. Mar;66(3):168-170.
  • David Calvo, Flórez JP, Valverde I, Rubín J, Pérez D, Vasserot MG, Rodríguez-Reguero J, Avanzas P, de la Hera JM, Gómez J, Coto E, Martínez-Camblor P, Morís C. Surveillance after Cardiac Arrest in patients with Brugada Syndrome without an implantable defibrillator: An alarm effect of the previous Syncope. Int J Cardiol. 2016 May 13;218:69-74.
  • Riobello C, Gómez J, Gil-Peña H, Tranche S, Reguero JR, de la Hera JM, Delgado E, Calvo D, Morís C, Santos F, Coto-Segura P, Iglesias S, Alonso B, Alvarez V, Coto E. KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort. Mol Cell Endocrinol. 2016 May 15;427:86-91.
  • Salgado R, Martín J, Martínez J, Alzueta J, Viñolas X, Fernández J, Molina M, Pérez L, Calvo D, García J. Small-Caliber Lead Failure After Generator Exchange. J Cardiovasc Electrophysiol. 2016;27(7):846-50.
  • Rodrigo M, Climent AM, Liberos A, Calvo D, Fernández-Avilés F, Berenfeld O, Atienza F, Guillem MS. Identification of Dominant Excitation Patterns and Sources of Atrial Fibrillation by Causality Analysis. Ann Biomed Eng. 2016;44(8):2364-76.
  • Loughlin G, Romaniega TD, Garcia-Fernandez J, Calvo D, Salgado R, Alonso A, Li X, Arenal A, González-Torrecilla E, Atienza F, Fernández-Avilés F. Immediate post-procedure bridging with unfractioned heparin versus low molecular weight heparin in patients undergoing radiofrequency ablation for atrial fibrillation with an interrupted oral anticoagulation strategy. J Interv Card Electrophysiol. 2016;45(2):149-58.
  • Ruiz-Salas A, Datino T, Peña-Hernández J, Calvo D, Alzueta J. Inappropriate shock due to late dislocation of electrode. Int J Cardiol. 2015 Nov 15;199:229-31.
  • Hernandez-Vaquero D, Garcia JM, Diaz R, Calvo D, Khalpey Z, Hernández E, Rodriguez V, Morís C, Llosa JC. Moderate patient-prosthesis mismatch predicts cardiac events and advanced functional class in young and middle-aged patients undergoing surgery due to severe aortic stenosis. J Card Surg. 2014;29:127-33.
  • Pascual I, Moris C, Avanzas P. Beta-Blockers and Calcium Channel Blockers: First Line Agents. Cardiovasc Drugs Ther. 2016;30:357-65.
  • Pascual I, Muñoz-García AJ, López-Otero D, Avanzas P, Jimenez-Navarro MF, Cid-Alvarez B, Del Valle R, Alonso-Briales JH, Ocaranza-Sanchez R, Hernández JM,Trillo-Nouche R, Morís C. Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up. J Geriatr Cardiol. 2015;12:340-5.
  • García-Álvarez A, Pereda D, García-Lunar I, Sanz-Rosa D, Fernández-Jiménez R, García-Prieto J, Nuño-Ayala M, Sierra F, Santiago E, Sandoval E, Campelos P, Agüero J, Pizarro G, Peinado VI, Fernández-Friera L, García-Ruiz JM, Barberá JA, Castellá M, Sabaté M, Fuster V, Ibañez B. Beta-3 adrenergic agonists reduce pulmonary vascular resistance and improve right ventricular performance in a porcine model of chronic pulmonary hypertension. Basic Res Cardiol. 2016 Jul;111(4):49.
  • López-Melgar B, Fernández-Friera L, Sánchez-González J, Vilchez JP, Cecconi A, Mateo J, Peñalvo JL, Oliva B, García-Ruiz JM, Kauffman S, Jiménez-Borreguero LJ, Ruiz-Cabello J, Fernández-Ortiz A, Ibáñez B, Fuster V. Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method. Atherosclerosis. 2016 May;248:230-7
  • García-Ruiz JM, Fernández-Jiménez R, García-Alvarez A, Pizarro G, Galán-Arriola C, Fernández-Friera L, Mateos A, Nuno-Ayala M, Aguero J, Sánchez-González J, García-Prieto J, López-Melgar B, Martínez-Tenorio P, López-Martín GJ, Macías A, Pérez-Asenjo B, Cabrera JA, Fernández-Ortiz A, Fuster V, Ibáñez B. Impact of the timing of metoprolol administration during ongoing STEMI on infarct size and ventricular function: a METOCARD-CNIC trial substudy with an experimental validation. J Am Coll Cardiol. 2016 May 10;67(18):2093-104.
  • Hausenloy DJ, Kharbanda R, Rahbek Schmidt M, Møller UK, Ravkilde J, Okkels Jensen L, Engstrøm T, Garcia Ruiz JM, Radovanovic N, Christensen EF, Sørensen HT, Ramlall M, Bulluck H, Evans R, Nicholas J, Knight R, Clayton T, Yellon DM, Bøtker HE. Effect of remote ischaemic conditioning on clinical outcomes in patients presenting with an ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur Heart J. 2015;36(29):1846-8.
  • Díaz-Molina B, Lambert JL, Víchez FG, Cadenas F, Bernardo MJ, Velasco E, Martín M, Morís C. Quality of life according to urgency status in de novo heart transplant recipients. Transplantation Proceedings 2016; 48: 3024-6.
  • Fernandez Alvarez R, Rubinos Cuadrado G, Alonso Arias R, Cascon Hernandez JA, Palomo Antequera B, Iscar Urrutia M, Casan Clara P. Snoring as a Determinant Factor of Oxidative Stress in the Airway of Patients with Obstructive Sleep Apnea. Lung. 2016; 194 (3): 469-73.
  • Moro-García MA, López Iglesias F, Avanzas P, Echeverría A, López-Larrea C, Morís de la Tassa C, Alonso-Arias R. Disease complexity in acute coronary syndrome is related to the patient's immunological status. Int J Cardiol. 2015; 189: 115-23.
  • Pascual I, Carro A, Avanzas P, Hernández-Vaquero D, Díaz R, Rozado J, Lorca R, Martín M, Silva J, Morís C. Vascular approaches for transcatheter aortic valve implantation. J Thorac Dis. 2017 May;9(Suppl 6):S478-S487.
  • Hernandez-Vaquero D, Diaz R, Pascual I, Rozado J, De la Hera JM, Leon V, Avanzas P, Martín M, García-Iglesias D, Calvo D, Silva J, Moris C. The Prevalence of Patient-Prosthesis Mismatch Can Be Reduced Using the Trifecta Aortic Prosthesis. Ann Thorac Surg. 2018 Jan;105(1):144-151.
  • Díaz R, Hernández-Vaquero D, Silva J, Pascual I, de la Hera JM, León V, Martín M, Barriales V, Colunga S, Del Valle R, Morís C. Real Structural Valve Deterioration of the Mitroflow Aortic Prosthesis: Competing Risk Analysis. Rev Esp Cardiol (Engl Ed). 2017 Dec;70(12):1074-1081.
  • García-Prieto J, Villena-Gutiérrez R, Gómez M, Bernardo E, Pun-García A, García-Lunar I, Crainiciuc G, Fernández-Jiménez R, Sreeramkumar V, Bourio-Martínez R, García-Ruiz JM, Del Valle AS, Sanz-Rosa D, Pizarro G, Fernández-Ortiz A, Hidalgo A, Fuster V, Ibanez B. Neutrophil stunning by metoprolol reduces infarct size. Nat Commun. 2017 Apr 18;8:14780.
Principal Investigator Title Funding Body Reference No Duration Amount
Daniel Hernández-Vaquero Medium-term degeneration of a bovine pericardial aortic prosthesis Instituto de Salud Carlos III PI15/00258 2016-2018 €22,385
Rebeca Alonso Arias Characterisation of the antigen specificity and functional activity of CD4+CD28null t-lymphocytes in patients with chronic heart failure: possible pathogenic implications Instituto de Salud Carlos III PI14/01566 2015-2017 €94,985
Rebeca Alonso Arias Quantitative and functional alterations in naïve t-lymphocytes in patients with secondary systemic inflammation resulting from chronic heart failure Instituto de Salud Carlos III PI17/00714 2018-2020 €188,457.50
Supervisors Title PhD Student Organisation Date of Viva
Julio Ángel Mayol MartínezJacobo Silva Guisasola

Luis Barneo Sierra

External validation of the EuroSCORE II in octogenarian patients who have undergone aortic valve replacement surgery Rocío Díaz Universidad Complutense 18-9-2017

SURTAVI - Clinical Trial Comparing Surgical Replacement and Transcatheter Aortic Valve Implantation.

CoreValve™ Evolut R™ FORWARD Study (FORWARD)

Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: A Multicentre Randomised Controlled Clinical Study. CONDI 2

  • Sponsor: Danish Strategic Research Council.
  • Completed in: 2014 – 2017

ATPCI Study -The Efficacy and Safety of Trimetazidine in Patients with Angina Pectoris having been Treated by Percutaneous Coronary Intervention.

  • Sponsor: SERVIER.
  • Completed in: 2014

GALILEO- Multicentre Study Comparing a Rivaroxaban-based Antithrombotic Strategy to an Antiplatelet-based Strategy after Transcatheter Aortic Valve Replacement (TAVR).

  • Bayer HealthCare.
  • Completed in: 2015

COMPLETE- Comparison of Complete vs Single Vessel Revascularisation after a Primary Angioplasty in Patients with Acute Coronary Syndrome

  • Sponsor: Population Health Research Institute (PHRI).
  • Completed in: 2015

Angiography Study of BioNIR Drug Eluting Stent System (NIREUS)

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

Oxygen carrying blood substitutes and their use as delivery vehicles

  • Inventors: Borja Ibáñez Cabeza, José Manuel García-Ruiz, Jauma Agüero Ramon-Llin, Rodrigo Fernández-Jiménez, Valentín Fuster Carulla, Enrique Lara-Pezzi, Juan Antonio Bernal Rodríguez, Carlos Galán-Arriola, Andrés Pun García, Enda Joseph Clinton
  • Ref No: EP17 382 040.8.
  • First application: 28 January 2017