Respiratory failure occurs frequently in intensive care units. Mechanical ventilation is used to aid respiration until lung function recovers. Although this strategy is widely used, it can contribute to poor functioning of the lungs and other organs. The main objective of our research is to find out which mechanisms are involved in respiratory failure in critically-ill patients and in the pulmonary lesions caused by ventilation, in order to improve current therapeutic approaches and discover new ones.
To achieve this aim, we have established several lines of research:
Mechanotransduction in the Alveolar Epithelium.
This project aims to characterise how the alveolar epithelium responds to mechanical stress at the molecular level and prevent the damage that can be caused.
ISPA Translational Research in Critically-Ill Patients Research Group Lines of Research
The Impact of Fragility on Mechanical Ventilation.
The comorbidity of patients who receive mechanical ventilation is increased, which is usually associated with poor prognoses. Using animal models and human samples, we are trying to identify the molecular pathways that exacerbate the consequences of mechanical ventilation in fragile populations.
Lung Repair
After a lesion, the lungs show a certain capacity for repair and regeneration. Through the use of mouse models and ex vivo experiments, we are trying to understand the mechanisms for lung repair after an acute lesion, particularly those related to cell proliferation and remodelling of the extracellular matrix.
Brain Damage Caused by Ventilation
Mechanical ventilation can create damage in distant tissues, such as the brain, through hormonal and neuronal responses. Our objective is to characterise the mechanisms involved in brain damage caused by mechanical ventilation, and understand how to identify patients at high risk of suffering such damage. We are also researching preventive strategies and new therapies.
AUTHORS: Blazquez-Prieto J, Lopez-Alonso I, Amado-Rodriguez L, Huidobro C, Gonzalez-Lopez A, Kuebler WM, Albaiceta GM.
TITLE: Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9.
Thorax 2018;73:321-330.
AUTHORS: Garcia-Prieto E, Lopez-Aguilar J, Parra-Ruiz D, Amado-Rodriguez L, Lopez-Alonso I, Blazquez-Prieto J, Blanch L, Albaiceta GM.
TITLE: Impact of recruitment on static and dynamic lung strain in acute respiratory distress syndrome.
Anesthesiology 2016;124:443-452.
AUTHORS: Amado-Rodriguez L, Bernal T, Lopez-Alonso I, Blazquez-Prieto J, Garcia-Prieto E, Albaiceta GM.
TITLE: Impact of initial ventilatory strategy in hematological patients with acute respiratory failure: A systematic review and meta-analysis.
Crit Care Med 2016;44:1406-1413.
AUTHORS: Blazquez-Prieto J, Lopez-Alonso I, Amado-Rodriguez L, Batalla-Solis E, Gonzalez-Lopez A, Albaiceta GM.
TITLE: Exposure to mechanical ventilation promotes tolerance to ventilator-induced lung injury by ccl3 downregulation.
Am J Physiol Lung Cell Mol Physiol 2015;309:L847-856
AUTHORS: Lopez-Alonso I, Aguirre A, Gonzalez-Lopez A, Fernandez AF, Amado-Rodriguez L, Astudillo A, Batalla-Solis E, Albaiceta GM.
TITLE: Impairment of autophagy decreases ventilator-induced lung injury by blockade of the nf-kappab pathway.
Am J Physiol Lung Cell Mol Physiol 2013;304:L844-852.
AUTHORS: Gonzalez-Lopez A, Lopez-Alonso I, Aguirre A, Amado-Rodriguez L, Batalla-Solis E, Astudillo A, Tomas-Zapico C, Fueyo A, dos Santos CC, Talbot K, Albaiceta GM.
TITLE: Mechanical ventilation triggers hippocampal apoptosis by vagal and dopaminergic pathways.
Am J Respir Crit Care Med 2013;188:693-702.
AUTHORS: Gonzalez-Lopez A, Garcia-Prieto E, Batalla-Solis E, Amado-Rodriguez L, Avello N, Blanch L, Albaiceta GM.
TITLE: Lung strain and biological response in mechanically ventilated patients.
Intensive Care Med 2012;38:240-247.
Interview with Guillermo Muñiz Albaiceta at ciberes.org(01/06/2018)
ESP
