Research Divisions

The Cardiorenal Axis

Group LeaderLocation and ContactMembersLines of ResearchNotable PublicationsProjectsPhD ThesesPatents and TrademarksNews

Eliecer Coto García

Genética Molecular – Laboratorio medicina

Hospital Universitario Central de Asturias (HUCA)

Av. Hospital Universitario, s/n, 33011 Oviedo, Spain.

Telephone: +34 985105500 EXT 37481

E-mail: eliecer.coto@sespa.es

Name Organisation Activity Euraxess classification
Coto García, Eliecer SESPA/Universidad de Oviedo Research/Clinical/Teaching R4
Cuesta Llavona, Elías FINBA Research R1
Gómez de Oña, Juan SESPA Research/Clinical R3
Rodríguez Reguero, Jose Julián SESPA Research/Clinical R2
Tranche Iparaguirre, Salvador SESPA Research/Clinical/Teaching R2
VIEJO DIAZ, MONICA SESPA Research/Clinical R2
Alonso González, María Belén FINBA Research No classification
García Lago, Claudia FINBA Research No classification
Iglesias Álvarez, Sara FINBA Research No classification

History of the Group

The group was formed because of a shared interest in the line of research, which focuses on care work in the field of cardiovascular and renal genomics.

Current and future priorities: to delineate the genetic bases of cardiovascular disease and kidney disease.

  • Genetics of cardiovascular disease and kidney disease
  • Immunogenetics
  • MicroRNAs
  • Cardiovascular epigenetics
  • Genetic association studies
  • Genetic epidemiology
  1. AUTHORS: Gómez J, Lorca R, Reguero JR, Morís C, Martín M, Tranche S, Alonso B, Iglesias S, Alvarez V, Díaz-Molina B, Avanzas P, Coto E.
    TITLE: Screening of the Filamin C Gene in a Large Cohort of Hypertrophic Cardiomyopathy Patients.
    JOURNAL: Circ Cardiovasc Genet. Apr;10(2). pii: e001584.
    YEAR: 2017
    ISSN: PMID: 28356264
    IMPACT FACTOR: 3.808
    QUARTILE AND FIELD: Q1 – Cardiovascular
  2. AUTHORS: Riobello C, Gómez J, Gil-Peña H, Tranche S, Reguero JR, de la Hera JM, Delgado E, Calvo D, Morís C, Santos F, Coto-Segura P, Iglesias S, Alonso B, Alvarez V, Coto E.
    TITLE: KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort.
    JOURNAL: Mol Cell Endocrinol. Mar 9. pii: S0303-7207(16)30055-7.
    YEAR: 2016
    ISSN: PMID: 26970180
    IMPACT FACTOR: 4.405
    QUARTILE AND FIELD: Q1 – Endocrinology
  3. AUTHORS: Coto-Segura P, González-Fernández D, Batalla A, Gómez J, González-Lara L, Queiro R, Alonso B, Iglesias S, Coto E.
    TITLE: Common and rare CARD14 gene variants affect the anti-TNF response among Psoriasis patients.
    JOURNAL: BRITISH J DERMATOLOGY 2016 Jul;175(1):134-41.
    YEAR: 2016
    ISSN: PMID: 26854129
    IMPACT FACTOR: 4.275
    QUARTILE AND FIELD: 1st DECILE – DERMATOLOGY
  4. AUTHORS: Batalla A, Coto E, González-Fernández D, González-Lara L, Gómez J, Santos-Juanes J, Queiro R, Coto-Segura P.
    TITLE: The Cw6 and late-cornified envelope genotype plays a significant role in anti-tumor necrosis factor response among psoriatic patients.
    JOURNAL: Pharmacogenet Genomics. 2015 Jun; 25(6):313-316.
    YEAR: 2015
    ISSN: PMID: 25794162
    IMPACT FACTOR: 3.481
    QUARTILE AND FIELD: Q1 – GENETICS
  5. AUTHORS: Batalla A, Coto E, González-Lara L, González-Fernández D, Gómez J, Aranguren TF, Queiro R, Santos-Juanes J, López-Larrea C, Coto-Segura P.
    TITLE: Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.
    JOURNAL: J Dermatol Sci. 2015 Nov; 80(2): 111-5.
    YEAR: 2015
    ISSN: PMID: 26347322
    IMPACT FACTOR: 3.739
    QUARTILE AND FIELD: Q1-DERMATOLOGY
  6. AUTHORS: Tavira B, Gómez J, Diaz-Corte C, Suarez B, Coronel D, Arias M, López-Larrea C, Iglesias S, Alonso B, Rodrigo E, Coto E.
    TITLE: ABCB1 (MDR-1) pharmacogenetics of tacrolimus in renal transplanted patients: a Next Generation Sequencing approach.
    JOURNAL: Clin Chem Lab Med. 2015 Sep 1; 53(10): 1515-9.
    YEAR: 2015
    ISSN: PMID: 25781547
    IMPACT FACTOR: 3.017
    QUARTILE AND FIELD: Q1-LABORATORY MED.
  7. AUTHORS: Gómez J, Gil-Peña H, Santos F, Coto E, Arango A, Hernandez O, Rodríguez J, Nadal I, Cantos V, Chocrón S, Vergara I, Madrid Á, Vazquez C, González LE, Blanco F.
    TITLE: Primary distal renal tubular acidosis: novel findings in patients studied by next-generation sequencing.
    JOURNAL: Pediatr Res. 2016 Mar; 79(3): 496-501.
    YEAR: 2016
    ISSN: PMID: 26571219
    IMPACT FACTOR: 2.761
    QUARTILE AND FIELD: Q1- PAEDIATRICS
  8. AUTHORS: Gómez J, Reguero JR, Coto E.
    TITLE: The Ups and Downs of Genetic Diagnosis of Hypertrophic Cardiomyopathy.
    JOURNAL: Rev Esp Cardiol (Engl Ed). 2016 Jan; 69(1): 61-8.
    YEAR: 2016
    ISSN: PMID: 26654849
    IMPACT FACTOR: 4.596
    QUARTILE AND FIELD: Q1-CARDIOLOGY
  9. AUTHORS: Pablo Flórez J, García D, Valverde I, Rubín J, Pérez D, González-Vasserot M, Reguero J, María de la Hera J, Avanzas P, Gómez J, Coto E, Morís C, Calvo D.
    TITLE: Role of syncope in predicting adverse outcomes in patients with suspected Brugada syndrome undergoing standardized flecainide testing.
    JOURNAL: Europace. 2018 Jun 1; 20(FI1): f64-f71.
    YEAR: 2018
    ISSN: PMID: 29309564
    IMPACT FACTOR: 4.021
    QUARTILE AND FIELD: Q2-CARDIOLOGY
  10. AUTHORS: Lorca R, Gómez J, Martín M, Cabanillas R, Calvo J, León V, Pascual I, Morís C, Coto E, R Reguero JJ.
    TITLE: Insights Into Hypertrophic Cardiomyopathy Evaluation Through Follow-up of a Founder Pathogenic Variant.
    JOURNAL: Rev Esp Cardiol (Engl Ed). 2018 Apr 6. pii: S1885-5857(18)30053-7.
    YEAR: 2018
    ISSN: PMID: 29631964
    IMPACT FACTOR: 4.596
    QUARTILE AND FIELD: Q1-CARDIOLOGY / CARDIOVASCULAR
  11. AUTHORS: Coto E, Calvo D, Reguero JR, Morís C, Rubín JM, Díaz-Corte C, Gil-Peña H, Alosno B, Iglesias S, Gómez J.
    TITLE: Differential methylation of lncRNA KCNQ1OT1 promoter polymorphism was associated with symptomatic cardiac long QT.
    JOURNAL: Epigenomics. 2017 Aug; 9(8): 1049-1057.
    YEAR: 2017
    ISSN: PMID: 28749187
    IMPACT FACTOR: 4.044
    QUARTILE AND FIELD: Q1-GENETICS
  12. AUTHORS: Batalla A, Coto E, Gómez J, Eirís N, González-Fernández D, Gómez-De Castro C, Daudén E, Llamas-Velasco M, Prieto-Perez R, Abad-Santos F, Carretero G, García FS, Godoy YB, Cardo LF, Alonso B, Iglesias S, Coto-Segura P.
    TITLE: IL17RA gene variants and anti-TNF response among psoriasis patients.
    JOURNAL: EPharmacogenomics J. 2018 Jan; 18(1): 76-80.
    YEAR: 2018
    ISSN: PMID: 27670766
    IMPACT FACTOR: 3.784
    QUARTILE AND FIELD: Q1-GENETICS
  13. AUTHORS: Calvo D, Rubín JM, Pérez D, Gómez J, Flórez JP, Avanzas P, García-Ruíz JM, de la Hera JM, Reguero J, Coto E, Morís C.
    TITLE: IL17RA gene variants and anti-TNF response among psoriasis patients.
    JOURNAL: Heart Rhythm. 2015 Feb; 12(2): 350-7.
    YEAR: 2015
    ISSN: PMID: 25460174
    IMPACT FACTOR: 4.391
    QUARTILE AND FIELD: Q1-CARDIOVASCULAR
  14. AUTHORS: Batalla A, Coto E, González-Lara L, González-Fernández D, Gómez J, Aranguren TF, Queiro R, Santos-Juanes J, López-Larrea C, Coto-Segura P.
    TITLE: Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.
    JOURNAL: J Dermatol Sci. 2015 Nov; 80(2): 111-5.
    YEAR: 2015
    ISSN: PMID: 26347322
    IMPACT FACTOR: 3.739
    QUARTILE AND FIELD: Q1-DERMATOLOGY
Principal Investigator Title Funding Body Reference No Duration Amount Researchers
Eliecer Coto García Hypertrophic cardiomyopathy: identification of new genes through exome sequencing. Instituto Salud Carlos III PI 12/00287 January 2013December 2015 €75,000 Eliecer Coto García
Julián R. Reguero
Juan Gómez de Oña
Eliecer Coto García Hypertrophic cardiomyopathy: mutation spectrum and functional characterisation of new genes identified through exome sequencing. Instituto Salud Carlos III PI15/00342 January 2016December 2018 €104,665 Eliecer Coto García
Julián R. Reguero
Juan Gómez de Oña
Juan Gómez de Oña Long noncoding RNAs in hypertrophic cardiomyopathy: the role of genetic variation in risk and as a modifier of phenotype. Instituto Salud Carlos III PI17/00648 January 2018December 2020 €95,000 Julián R. Reguero
Juan Gómez de Oña
Eliecer Coto García REDINREN (Renal Research Network) Instituto Salud Carlos III RD-16/009/005 January 2018December 2020 €75,000 Eliecer Coto García
Julián R. Reguero
Juan Gómez de Oña
Supervisors Title PhD Student Organisation Date of Viva International Honours
Eliecer Coto García
Julián Rodríguez Reguero
Identification of new genes in hypertrophic cardiomyopathy through exome sequencing Juan Gómez de Oña Universidad de Oviedo February 2017 No
Eliecer Coto García
Julián Rodríguez Reguero
Correlation between genotype and phenotype in non-compaction cardiomyopathy Rebeca Lorca García Universidad de Oviedo January 2018 No
Eliecer Coto García
Pablo Coto Segura
IL17 pathway genes in psoriasis and response to biological treatments Ana Batalla Cebey Universidad de Oviedo February 2016 No
Eliecer Coto García
Pablo Coto Segura
Genetics of the TNF/NFKB pathway in psoriasis and response to biological treatments Leire González Lara Universidad de Oviedo September 2018 No
Eliecer Coto García
Pablo Coto Segura
The pharmacogenetics of anti-TNFs in psoriasis Noemí Eirís Salvado Universidad de Oviedo June 2017 No