Research Divisions

Pharmacology of Therapeutic Targets

Group LeaderLocation and ContactMembersLines of ResearchNotable PublicationsProjectsPhD ThesesNews

Ana Isabel Baamonde Arbaiza

Ana I. Baamonde obtained a degree in Medicine and Surgery from the Universidad de Oviedo, for which she presented her dissertation on "antagonists of calcium and sodium nitroprusside in innervated and non-innervated intestinal smooth muscle in vitro” in 1983. She completed her PhD thesis on "the influence of different hormonal states on pain, temperature and behaviour: the relationship to opioids and modification due to stress” in 1988.

Between 1989 and 1990, she realised a postdoctoral fellowship on "effects mediated by delta opioid receptors in vivo" at the Organic Chemistry Laboratory of the Université René Descartes in Paris.

She has worked on several lines of research over the course of her career: drugs that modulate calcium-dependent processes in smooth and striated muscle (1983); the pharmacology of experimental pain – endogenous opioids (1984-90); the effects of steroids on GABA and opioid receptors (1991-98); calmodulin inhibitors (1995-98), and neoplastic pain (since 1999).

Facultad de Medicina, Universidad de Oviedo

Julián Clavería 6

33006 Oviedo, Spain.

Telephone: +34 985102755


Name Organisation Activity Euraxess classification
Baamonde Arbaiza, Ana Universidad de Oviedo Research/Teaching R3
Barreiro Alonso, Eva SESPA Research/Clinical R2
Bordallo Landa, Javier Universidad de Oviedo Research/Teaching R3
Brid Castañón, Teresa SESPA Research/Clinical R2
Cantabrana Plaza, Begoña Universidad de Oviedo Research/Teaching R3
Fierro Roza, José Fernando Universidad de Oviedo Research/Teaching R3
Gayoso Rodríguez, María Antonieta SESPA Research/Clinical R2
González Rodríguez, Sara Universidad de Oviedo Research R2
Hidalgo Balsera, Agustín Universidad de Oviedo Research/Teaching R3
Iglesias Carbajo, Ana Isabel SESPA Research/Clinical R2
Menéndez Antolín, Luis Universidad de Oviedo Research/Teaching R3
Sánchez Fernández, Manuel Universidad de Oviedo Research/Teaching R3
Andrés Gómez, Teresa Universidad de Oviedo Research No classification
González García, María SESPA Research/Clinical No classification
Suárez García, Lorena Universidad de Oviedo Research No classification

Assessment of the effects produced by analgesics.

  1. Evaluating the effect and determining the mechanisms involved in the analgesia produced by the chemokine CCL4.
  2. Studying the possible synergy between CCL4 and enkephalin-degradation inhibitors in relation to the analgesic effect and possible anti-tumour action
  3. Assessing other possibilities for producing analgesia related to CC-series chemokines

The role of polyamines in the physiopathology of inflammatory and tumour processes. The regulation of ion channels by sexual steroids in tumour cell models.

  1. Characterising the regulation of ion channels by sexual steroids in tumour cell models (pituitary adenomas; breast and prostate cancer).
  2. Studying the influence of trace endogenous polyamines and amines on inflammatory and tumour processes, and their possible role as physiopathological markers.

Social studies of medicinal products.

Delivering the Social Pharmacology course, which deals with a range of issues related to the social repercussions of medicinal products, as well as potential social influences upon their use.

Research on Medical Education

  1. Communication of a strategy for teaching the relevant literature in medical education.
  2. Analysis of the consistency between the profile of students admitted onto the Medicine degree and the decisions students express about studying medicine.
  3. Analysis, through student questionnaires, of the reasons for enrolling on the Medicine degree, with a particular focus on features that demonstrate a vocation for medicine.
  4. Communication of studies conducted on the research competencies included in the Medicine degree and the experience gained as part of the Oviedo qualification.
  5. Analysis of the educational value of reading as part of the training of future doctors.
  6. Early immersion in clinical practice through the production of medical histories.
  7. Evaluation of the role of reading works of art in the emotional education of medical students.
  8. Evaluation of the role of producing scientific and medical essays in building medical students’ capacity for critical analysis.
  • Pevida M, González-Rodríguez S, Lastra A, García-Suárez O, Hidalgo A, Menéndez L, Baamonde A. Involvement of Spinal Chemokine CCL2 in the Hyperalgesia Evoked by Bone Cancer in Mice: A Role for Astroglia and Microglia. Cell Mol Neurobiol 2014;34:143-156
  • Pevida M, Lastra A, Hidalgo A, Baamonde A, Menéndez L. Spinal CCL2 and microglial activation are involved in paclitaxel-evoked cold hyperalgesia. Brain Res Bull. 2013;95:21-27:
  • Pevida M, Lastra A, Meana A, Hidalgo A, Baamonde A, Menéndez L. The chemokine CCL5 induces CCR1-mediated hyperalgesia in mice inoculated with NCTC 2472 tumoral cells. Neuroscience 2014;259:113-125
  • María Llorián-Salvador, Marta Pevida, María Teresa Fernández-García, Ana Lastra, Álvaro Obaya, Santiago Cal, Agustín Hidalgo, Luis Menéndez and Ana Baamonde.Hypernociceptive responses following the intratibial inoculation of RM1 prostate cancer cells in mice. Prostate 2015;75:70-83
  • Llorián-Salvador M, González-Rodríguez S, Lastra A, Fernández-García MT, Hidalgo A, Menéndez L, Baamonde A. Involvement of CC Chemokine Receptor 1 and CCL3 in Acute and Chronic Inflammatory Pain in Mice. Basic Clin Pharmacol Toxicol 2016;119:32-40
  • Llorián-Salvador M, Pevida M, González-Rodríguez S, Lastra A, Fernández-García MT, Hidalgo A, Baamonde A, Menéndez L. Analgesic effects evoked by a CCR2 antagonist or an anti-CCL2 antibody in inflamed mice. Fundam Clin Pharmacol. 2016;30(3):235-47
  • Sánchez M, Suárez L, Cantabrana B, Bordallo J. Estradiol modified prolactin secretion independently of action potentials and Ca2+ and blockade of outward potassium currents in GH3 cells. Naunyn-Schmiedeberg's Arch Pharmacol 2017;390:95-104.
  • Sánchez M, Suárez L, Andrés MT, Flórez BH, Bordallo J, Riestra S, Cantabrana B. Modulatory effect of intestinal polyamines and trace amines on the spontaneous phasic contractions of the isolated ileum and colon rings of mice. Food & Nutrition Research 2017;61: 1321948.
  • González-Rodríguez S, Poras H, Menéndez L, Lastra A, Ouimet T, Fournié-Zaluski MC, Roques BP, Baamonde A. Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain. Scand J Pain. 2017;14:25-38.
  • González-Rodríguez S, Álvarez MG, García-Domínguez M, Lastra A, Cernuda-Cernuda R, Folgueras AR, Fernández-García MT, Hidalgo A, Baamonde A, Menéndez L. Hyperalgesic and hypoalgesic mechanisms evoked by the acute administration of CCL5 in mice. Brain Behav Immun. 2017;62:151-161.
  • Brid T, Sacristán de Lama MP, González N, Baamonde A. Topical gabapentin as add-on therapy for trigeminal neuralgia. A case report. Pain Med. 2017;18:1824-1826.
Principal Investigator Title Funding Body / Reference No Duration Amount
Ana Baamonde Arbaiza Mechanisms involved in the hyperalgesic effect of the chemokine CCL2 in experimental neoplastic pain FICYT (Foundation for the Promotion of Applied Scientific Research and Technology in Asturias) - FEDER (Spanish Federation of Rare Diseases)


2015-2017 €64,000
Manuel Sánchez Fernández Biomedical applications of artificial tissue models in toxicity and permeability tests for topical preparations. BIO-TEAR project. Fundación Universidad de Oviedo


March 2017-June 2018 €10,000
Ana Baamonde Arbaiza Exploration of the analgesic potential of CC-series chemokines SAF 2017-86799-R January 2018-December 2021 €100,000
Supervisors Title PhD Student Organisation Date of Viva
Ana Baamonde Involvement of the CCL2 and CCL5 chemokines in experimental neoplastic pain models Marta Pevida López Universidad de Oviedo 2014
Ana Baamonde Involvement of the CCL2 and CCL3 chemokines in the pain derived from the intraosseous inoculation of prostate cancer cells and in experimental inflammatory pain María Llorián Salvador Universidad de Oviedo 2016
Agustín Hidalgo Balsera The prevalence of inappropriate polypharmacy and drug prescription according to the STOPP-START criteria. Francisco Muñoz González Universidad de Oviedo 12/6/2017
Agustín Hidalgo Balsera Analysis of changes in usage of drugs affected by the informative safety notices issued by AEMPS (Spanish Agency for Medicinal Products and Medical Devices) from 2003 to 2015 in primary healthcare in Asturias Ana Isabel Iglesias Carbajo Universidad de Oviedo 14/07/2017