Rosa M. Sáinz obtained her PhD at the Universidad de Oviedo. She was a postdoctoral fellow at the Instituto Universitario de Oncología de Asturias (IUOPA) from 2000 to 2001, before receiving a grant from the Fulbright-MEC programme to complete a postdoctoral fellowship at the Health Science Center in San Antonio (TX, US) between 2001 and 2004. She returned to the Universidad de Oviedo in 2005, where she worked as a Ramón y Cajal researcher until 2009 and she has been a Tenured Lecturer in Cell Biology since 2010.
Since then, Dr Sainz’s research has focused on the role of redox metabolism in cell survival and the signalling mechanisms involved in this process, as well as the acquisition of resistance phenotypes, and cell-differentiation mechanisms in tumour cells. These lines of research have been funded by public research bodies at the regional (Asturian Regional Research Plan), national (Instituto de Salud Carlos III Health Research Fund, Ministry of Economic Affairs and Digital Transformation) and international (JPI ERA-HDHL ).
She has authored over 90 publications in scientific journals, with over 10,000 cumulative citations, has a h-index of 42 and is one of the leading Spanish scientific authors in the field of Endocrinology and Metabolism. She is currently the academic secretary of IUOPA and is on the board of directors of the Sociedad Española de Biología Celular (Spanish Society of Cell Biology).
Facultad de Medicina
Julián Clavería, 6 33006 Oviedo, Spain.
Name | Organisation | Activity | Euraxess classification |
---|---|---|---|
Alcón Rodríguez, Sergio | FINBA | Research | R1 |
Álvarez Artime, Alejandro | Universidad de Oviedo | Research | R1 |
Artime Naveda, Francisco | Universidad de Oviedo | Research | R1 |
Cernuda Cernuda, Rafael | Universidad de Oviedo | Research/Teaching | R3 |
García Alonso, José Ignacio | Universidad de Oviedo | Research/Teaching | R3 |
Hevia Sánchez, David | Universidad de Oviedo | Research/Teaching | R2 |
Mayo Barrallo, Juan Carlos | Universidad de Oviedo | Research/Teaching | R3 |
Morán Álvarez, Alba | Universidad de Oviedo | Research | R1 |
Quirós González, Isabel | Universidad de Oviedo | Research/Teaching | R2 |
Rodas Sánchez, Laura Covadonga | Universidad de Oviedo | Research | R1 |
Rodríguez González, Pablo | Universidad de Oviedo | Research/Teaching | R3 |
Sainz Menéndez, Rosa María | Universidad de Oviedo | Research/Teaching | R4 |
The main interest of the ‘Redox Biology and Metabolism in Cancer’ research group is exploring the role of reactive oxygen species as physiological agents in cell signalling mechanisms within biological processes.
- Alvarez-Artime A, Cernuda-Cernuda R, Artime-Naveda F, Cepas V, Gonzalez-Menendez P, Fernandez-Vega S, Quiros-Gonzalez I, Sainz RM, Mayo JC. Melatonin-induced cytoskeleton reorganization leads to inhibition of melanoma cancer cell proliferation. International Journal of Molecular Sciences, (2020) 21 (2) IF: 4.183 Q2
- Cepas V, Collino M, Mayo JC, Sainz RM. Redox signaling and Advanced Glycation Endproducts (AGEs) in diet-related diseases. Antioxidants (2020) 9(2), 142. IF: 4.520
- Bouzas-Ramos D, Cigales-Canga J, Mayo JC, Sainz RM, Ruiz-Encinar J, and Costa-Fernandez JM*. Carbon Quantum Dots codoped with nitrogen and Lanthanides for Multimodal Imaging. Advanced Functional Materials (2019), 29, 1903884. IF: 15.621, D1
- Gonzalez-Menendez P, Hevia D, Alonso-Arias R, Alvarez-Artime A, Rodriguez-Garcia A, Kinet S, Gonzalez-Pola I, Taylor N, Mayo JC, Sainz RM (2018). GLUT1 protects prostate cancer cells from glucose deprivation-induced oxidative stress. Redox Biology. 17, pp.112-127. IF: 7.126 D1
- Moro-García MA, Mayo JC, Sainz RM, Alonso-Arias R (2018). Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes. Frontiers Immunol. 9, pp.339. IF: 6.429
- Mayo JC, Sainz RM, Gonzalez Menendez P, Cepas V, Tan DX, Reiter RJ (2017). Melatonin and sirtuins: A “not-so unexpected” relationship. Journal of Pineal Res. 62(2). IF: 11.613 D1
- Gonzalez-Menendez P, Hevia D, Mayo JC, Sainz RM. (2017). The dark side of glucose transporters in prostate cancer: are they a new feature to characterize carcinomas? International Journal of Cancer. 142-12, pp.2414-2424. IF: 7.360
- Mayo JC, Hevia, D, Quiros-Gonzalez I, Rodriguez-Garcia, A, Gonzalez-Menendez P, Cepas V, Gonzalez-Pola I, Sainz RM (2017). IGFBP3 and MAPK/ERK signaling mediates melatonin-induced antitumor activity in prostate cancer. Journal of Pineal Research. IF: 11.613. D1
- Hevia D, Gonzalez-Menendez P, Fernandez-Fernandez M, Cueto S, Rodriguez-Gonzalez P, Garcia-Alonso JI, Mayo JC, Sainz RM (2017). Melatonin Decreases Glucose Metabolism in Prostate Cancer Cells: A 13C Stable Isotope-Resolved Metabolomic Study. International Journal of Molecular Science. 18-8, pp.1620-1639. IF: 3.68 Q2
- Rodriguez-Garcia A, Hevia D, Gonzalez-Menendez P, Coppo L, Lu J, Holmgren A, Sainz RM (2017). Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells. Redox Biology. 12, pp.634-647. IF: 7.126 D1
- Miar A, Hevia D, Muñoz-Cimadevilla H, Astudillo A, Velasco J, Sainz RM, Mayo JC (2015). Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon and lung cancer. Free Radical Biology & Medicine. 85, pp.45- 55. IF: 5.784
- Hevia D, Gonzalez-Menendez P, Quiros-Gonzalez I, Miar A, Rodriguez-Garcia A, Tan DX, Reiter RJ, Mayo JC, Sainz RM (2015). Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer. Journal of Pineal Research. 58-2, pp.234-250. IF: 9.6 D1
- Gonzalez-Menendez P, Hevia D, Rodriguez-Garcia A, Mayo JC, Sainz RM* (2014). Regulation of GLUT Transporters by Flavonoids in Androgen-Sensitive and -Insensitive Prostate Cancer Cells. 155-9, pp.3238-3250. IF: 4.503
Establishing the role of Thioredoxin Interacting Protein (TXNIP) as a bridge between diabetes and redox signaling in the inhibition of prostate cancer
PI | Rosa M. Sainz, Juan C. Mayo |
Team | Rafael Cernuda Cernuda, Isabel Quirós-Gonzalez, David Hevia, Miguel Alvarez Múgica, Mario Dominguez Esteban |
Funding body | MICIU-AEI |
Reference No | PID2019-111418RB-I00 |
Date | 1/9/2020 – 31/8/2023 |
Budget | €167,706 |
The relevance of hydrogen peroxide signalling and the “redoxisome” in the function of androgens in normal cells and cancer cells
PI | Rosa M. Sainz |
Team | Juan Carlos Mayo Barrallo, Jose Manuel García Fernandez, Rafael Cernuda Cernuda, Manuel Rivas Del Fresno, David Hevia Sánchez. |
Funding Body | MINECO |
Reference No | MINECO-17-BFU2016-79139-R |
Date | 30/12/2016 – 31/12/2020 |
Budget | €133,100 |
SALIVAGES – Innovative technological approaches to the validation of salivary AGEs as novel biomarkers for risk factors in diet-related diseases
PI | Rosa M. Sainz |
Team | Juan Carlos Mayo Barrallo, Vanesa Cepas López |
Funding Body | ERA-HDHL_MINECO |
Reference No | MINECO-17-PCIN-2016-164 |
Date | 01/12/2016 – 31/12/2020 |
Budget | €148,000 |
The synthesis of isotopically-enriched compounds as disease biomarkers, for application in clinical analysis methods based on isotope dilution analysis and mass spectrometry
PI | Pablo Rodríguez González |
Team | José Ignacio García Alonso |
Funding Body | ISC-Science S.L. |
Reference No | FUO-091-17 |
Date | 01/03/2017 – 28/02/2018 |
Budget | €26,819 |
Peripheral endometriosis markers related to inflammation
PI | Isabel Quirós González |
Funding Body | ISPA/FINBA |
Date | 01/01/2018 – 31/12/2018 |
Budget | €6000 |
Enriched stable isotopes
PI | José Ignacio García Alonso |
Team | Rosa María Sainz Menéndez, Juan Carlos Mayo Barrallo, Pablo Rodríguez González, Rafael Cernuda Cernuda, David Hevia Sánchez, Isabel Quirós González, Vanesa Cepas López, Laura Covadonga Rodas Sánchez, Alejandro Álvarez Artime |
Funding Body | Gobierno del Principado de Asturias |
Reference No | IDI/2018/000239 |
Date | 01/01/2018 – 31/12/2020 |
Budget | €141,900 |
Determination of the concentration and isotopic fractionation of mercury species in biological samples by coupling gas chromatographs with different mass spectrometers
PhD Student: Silvia Queipo Abad
Supervisor: José Ignacio García Alonso
Universidad de Oviedo – Faculty of Chemistry
July 2019
Development of analytical strategies for the quantification of biomolecules through liquid chromatography, isotope dilution and mass spectrometry
PhD Student: Amanda Suárez Fernández
Supervisors: José Ignacio García Alonso, Pablo Rodríguez González
Universidad de Oviedo – Faculty of Chemistry
December 2019
Regulation of facilitative glucose transporters (glut) during prostate tumour progression
PhD Student: Pedro González Menéndez
Supervisors: Rosa María Sainz Menéndez, Juan Carlos Mayo Barrallo, David Hevia Sánchez
Universidad de Oviedo – Faculty of Medicine. Instituto Universitario de Oncología del Principado de Asturias
April 2017
International Honours
Outstanding PhD Award
Changes in SOD2 levels during carcinogenesis in TRAMP mice: redox imbalance as a possible new biomarker for tumour progression and metastasis
PhD Student: Ana Belén Miar Cuervo
Supervisors: Rosa María Sainz Menéndez, Juan Carlos Mayo Barrallo
Universidad de Oviedo
February 2015
Summa cum laude
International Honours
Redox control of cell survival in prostate cancer
PhD Student: Aida Rodríguez García
Supervisors: Rosa María Sainz Menéndez, Juan Carlos Mayo Barrallo
Universidad de Oviedo
May 2015
Summa cum laude
International Honours
Outstanding PhD Award
The biological activity of berry extracts in cells, animals and human samples
Type: University-Company FUO-286-17
Company Providing Funding: BQC S.L.
Duration: 1/7/2017 – 31/1/2018
Lead Researcher: Juan Carlos Mayo Barrallo
Total Project Cost: €12,610
Development of analytical methods for the new Bilastine synthesis pathway
Type: University-Company FUO-316-18
Company Providing Funding: Faes Pharma S.A.
Duration: 20/9/2018 – 31/4/2019
Lead Researcher: José Ignacio García Alonso
Total Project Cost: €20,859
- BIOQUOCHEM S.L. (http://www.bioquochem.com/)
Date created: 14/05/2015 - ISC-SCIENCE (Innovative Solutions in Chemistry, www.isc-science.com)
Date created: 16/05/2003
The use of melatonin in the treatment of neurodegenerative diseases
Inventors: C. Rodríguez, J.C. Mayo, R.M. Sáinz, H. Uría and I. Antolín
Application Number: P97012012
Priority Country: Spain
Priority Date: 1996
Owner: Universidad de Oviedo
Countries in which the patent applies: Spain
Anti-tumour activity in prostate cancer of the phenolic and polyphenolic compounds in cider
Inventors: Hevia D, Sainz RM, Mayo JC, Quiros I
Application Number: O-293-2008
Application Date: 26/06/2008
Application Date: 5/9/2008
Anti-tumour activity in prostate cancer of the phenolic and polyphenolic compounds in beer
Inventors: Hevia D, Sainz RM, Mayo JC, Quiros I
Application Number: O-294-2008
Application Date: 26/06/2008
Application Date: 5/9/2008
Method for the absolute quantification of peptides through tandem mass spectrometry, and its uses
Inventors: J.I. García Alonso, A. González Antuña and P. Rodríguez González
Application Number: P201400239
Priority Date: 21/03/2014
Owner: Universidad de Oviedo
- European Researchers’ Night (27/9/2019)